This website was discontinued on 20/12/2022. Visit the new website at www.fct.pt.
The information may be unavailable due to the results not being approved or confirmed. In particular, when a call includes regions where projects are cofunded by EC funds and others where that is not the case, confirmation or approval may be not simultaneous.
Neuronal Ceroid Lipofuscinosis: Molecular, biochemical and functional studies. Maria Gil Roseira Ribeiro, Instituto Nacional de Saúde Dr. Ricardo Jorge (INSARJ). €65,021.
Impact of mRNA mistranslation on cell degeneration and evolution. Manuel António Silva Santos, Universidade de Aveiro (UA). €94,717.
Molecular mechanisms involved in the transcriptional regulation of the human CYP46 gene - Implications in brain cholesterol homeostasis. Elsa Margarida Teixeira Rodrigues, Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa). €49,730.
Acute and long-term injury of bilirubin to nerve cells - Looking for sensors, susceptibilities and modulators. Dora Brites, Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa). €79,524.
Tolerance induction in autoimmunity: reprogramming the immune system with monoclonal antibodies. Luis Ricardo Silva Graca, Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa). €85,219.
Lentiviral vectors for gene silencing in polyglutamine disorders: Ataxin-3 gene silencing by lentiviral vectors-mediated delivery of double-stranded RNAs. LUÍS FERNANDO MORGADO PEREIRA DE ALMEIDA, Centro de Neurociências e Biologia Celular (CNBC/UC). €30,000.
Modulation of atherosclerosis by the protective gene heme oxygenase-1: Molecular mechanisms and therapeutic applications. Miguel Amado Franco Parreira Soares, Fundação Calouste Gulbenkian (FCG). €63,335.
Proteomics of Chronic Lung Diseases Leading to Biomarkers and Therapeutic Target Discovery. Deborah Penque, Pró-INSA, Associação para a Promoção da Investigação em Saúde (Pró-INSA/INSARJ). €94,932.
Molecular Genetics of Autosomal Dominant Neurodegenerative Diseases Characterized mainly by Ataxia. Isabel Alexandra Azevedo Silveira, Instituto de Biologia Molecular e Celular (IBMC/UP). €94,997.
Molecular pathways involved in Gordon syndrome, a familial hypertension disease. Peter Jordan, Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa). €20,520.
Multiple isoforms of CD6 that arise from alternative splicing: their role in the regulation of T cell signaling and at the immunological synapse. Alexandre Carmo, Instituto de Biologia Molecular e Celular (IBMC/UP). €91,079.
Somatic expression of PDHA2 gene - a long dreamed therapy. Isabel Maria Antolin Martins-de-Carvalho, Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa). €59,309.
Filling in the GAP: the missing link between intercellular communication and diabetic retinopathy. Paulo Pereira, Associação para a Investigação Biomédica e Inovação em Luz e Imagem (AIBILI). €39,338.
Search for TTR ligands modulators of amyloidogenesis. Maria Rosário Almeida, Instituto de Biologia Molecular e Celular (IBMC/UP). €81,831.
Study of the mechanism by which the proximity of the nonsense codon to the AUG inhibits the nonsense-mediated mRNA decay. Luísa Romão, Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa). €34,382.
Study of the possible environmental and molecular mechanisms responsible for Insulin Resistance, Type 2 Diabetes and Obesity in Portugal. EUGÉNIA MARIA LOURENÇO DE CARVALHO, Centro de Neurociências e Biologia Celular (CNBC/UC). €73,750.
Regulation of mRNA processing and transport within the nucleus. Maria Carmo-Fonseca, Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa). €43,000.
Bile Acid Mediated Inhibition of Neuronal Apoptosis. Cecília Maria Pereira Rodrigues, Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa). €60,427.
Type 1 Diabetes: immunopathology and genetic susceptibility. CARLOS AUGUSTO GOMES BARBOSA DA PENHA GONÇALVES, Fundação Calouste Gulbenkian (FCG). €53,600.
Inflammatory components in the biology of regulatory T cells and the prevention of auto-immune disease. Jocelyne Demengeot, Fundação Calouste Gulbenkian (FCG). €47,500.
In Vivo Molecular Dissection of Mitotic Spindle Morfogenetic Pathways - Implications for Aneuploidy and Cancer. Helder Jose Martins Maiato, Instituto de Biologia Molecular e Celular (IBMC/UP). €94,984.
Study of genetic diversity of the Azorean population. Luisa Maria Quental Mota Vieira, Hospital do Divino Espírito Santo de Ponta Delgada, EPE (HDESPD, EPE). €49,920.
CFTR Interactome. Margarida Sofia Pereira Duarte Amaral, Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa). €82,604.
Efflux-pumps in drug resistance of Mycobacterium tuberculosis: Molecular characterisation of the efflux mechanism and use of efflux inhibitors as new anti-tubercular compounds. Miguel Viveiros Bettencourt, Instituto de Higiene e Medicina Tropical (IHMT/UNL). €52,350.
Mechanism and Utility of a Novel Herpes Virus Gene Inducing Apoptosis. Robert Michael Evans Parkhouse, Fundação Calouste Gulbenkian (FCG). €61,189.
Genomic and post-genomic in-depth molecular characterization of the RAS/RAF/ERK and the PI3 Kinase/AKT signalling transduction pathways in aggressive thyroid tumours. Ginesa Garcia Rostan, Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP). €93,100.
Characterisation and applications of a novel hemangioblast-specific transcriptional enhancer. Ana Teresa Fernandes Nunes Tavares, Fundação Calouste Gulbenkian (FCG). €46,500.
Autoantibody repertoires and regulatory T-cells in human and murine lupus. Constantin Fesel, Fundação Calouste Gulbenkian (FCG). €57,000.
Cell cycle checkpoints during human oocyte meiosis in vitro. Alberto Barros, Faculdade de Medicina da Universidade do Porto (FM/UP). €66,092.
Molecular determinants of ataxin-3 aggregation and toxicity in Machado-Joseph´s disease. Sandra de Macedo Ribeiro, Instituto de Biologia Molecular e Celular (IBMC/UP). €94,996.
T cell production in HIV immunodeficiency. Ana Espada de Sousa, Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa). €72,417.
Study of the involvement of the molecular chaperones and the ubiquitin-proteasome system in Machado-Joseph disease. Patrícia Espinheira de Sá Maciel, Universidade do Minho (UM). €77,900.
Hoxb4 in the formation of hematopoietic stem cells. Moises Mallo, Fundação Calouste Gulbenkian (FCG). €43,252.
Listeria as a model for the analysis of pathogen and host factors that determine the fate of infections. Didier Cabanes, Instituto de Biologia Molecular e Celular (IBMC/UP). €94,833.
Genomic Imprinting in human spermatogenesis. Mário Manuel da Silva Leite Sousa, Faculdade de Medicina da Universidade do Porto (FM/UP). €73,920.
Gene expression profiles in stage specific male germ cells using the microarray technology. Filipa Abreu Gomes de Carvalho, Faculdade de Medicina da Universidade do Porto (FM/UP). €39,713.
Functional genomics in malaria - an unbias RNAi screen to determine the required host cell molecules and pathways for Plasmodium sporozoite fully development inside hepatocytes. Maria Manuel Dias da Mota, Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa). €85,525.
Expression and Function of Ubiquitin Conjugating Enzyme hsUbc6e. John Vincent Fleming, Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa). €22,000.
Impact of diabetes mellitus on myocardial remodeling induced by cardiac overload and ischemia. Joaquim Adelino Correia Ferreira Leite Moreira, Faculdade de Medicina da Universidade do Porto (FM/UP). €62,605.
Regulation of IL-10 Expression at the allel level. Matthias Haury, Fundação Calouste Gulbenkian (FCG). €57,000.
Genetics of the Innate Immune Response in the Non-Obese Diabetic Mouse. CARLOS AUGUSTO GOMES BARBOSA DA PENHA GONÇALVES, Fundação Calouste Gulbenkian (FCG). €60,000.
The Cell Biology and Molecular Basis of Neural Tube Closure in the Chick Embryo. Joaquin Maria Rodriguez-Leon, Fundação Calouste Gulbenkian (FCG). €61,246.