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R&D Projects

Call for Projects on Clinical Translational Research, in the Framework of the Cooperation Agreement between Portugal and Harvard Medical School - 2011

Painel de Avaliação do Concurso de Projectos de Investigação Clínica e de Translação, no Âmbito do Acordo de Cooperação entre Portugal e a Harvard Medical School - 2011

Coordination

Lee Marshall Nadler*

Evaluation

Frances Elizabeth Jensen
Lee Marshall Nadler*
Rui Victorino
Stephen Copan Harrison

Projects assigned

HMSP-ICT/0001/2011

Induction of Immune Tolerance in Human Allogeneic Hematopoietic Stem Cell Transplantation
João Mascarenhas Forjaz de Lacerda
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

HMSP-ICT/0002/2011

Prognostic and Protective roles of Clusterin Against Complications of Obesity/Diabetes
John Griffith Jones
Centro de Neurociências e Biologia Celular (CNBC/UC)

HMSP-ICT/0007/2011

Brain barriers and aging: implications for Alzheimer's disease and immunotherapy
Joana de Almeida Santos Pacheco Palha
Universidade do Minho (UM)

HMSP-ICT/0010/2011

Characterization of human induced pluripotent stem cells derived from Huntington's disease patients
Ana Cristina Carvalho Rego
Centro de Neurociências e Biologia Celular (CNBC/UC)

HMSP-ICT/0013/2011

Comparative Use of Technologies for Coronary Heart Disease
Altamiro Manuel Rodrigues Costa Pereira
Faculdade de Medicina da Universidade do Porto (FM/UP)

HMSP-ICT/0016/2011

Dynamic Fabricae - Dynamic fabrics for the detection and prevention of complications in immobilized people
Miguel Ângelo Fernandes Carvalho
Universidade do Minho (UM)

HMSP-ICT/0017/2011

A novel model for Schizophrenia: defects in stargazin-mediated homeostatic plasticity.
Ana Luisa Carvalho
Centro de Neurociências e Biologia Celular (CNBC/UC)

HMSP-ICT/0018/2011

TREAT LIVER DISEASES BY TARGETING HEPATOCYTE NECROPTOSIS
Cecília Maria Pereira Rodrigues
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

HMSP-ICT/0020/2011

Crosstalk between adenosine A2A receptors and alpha-synuclein: therapeutic implications for Parkinson´s disease
Luisa Vaqueiro Lopes
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

HMSP-ICT/0021/2011

Novel approaches to scrutinize microbe-host interactions during Chlamydia trachomatis infection
JOÃO PAULO DOS SANTOS GOMES
Pró-INSA, Associação para a Promoção da Investigação em Saúde (Pró-INSA/INSARJ)

HMSP-ICT/0022/2011

Role of Scavenger Receptors in Human Listeriosis: Towards Innovative Therapeutic Strategies
Didier Cabanes
Instituto de Biologia Molecular e Celular (IBMC/UP)

HMSP-ICT/0023/2011

Epigenetics and proteomics in diabetes-induced impaired wound healing
Raquel Soares
Faculdade de Medicina da Universidade do Porto (FM/UP)

HMSP-ICT/0024/2011

NextGen-Cytogenetics enters developmental disorder care
Dezso David
Pró-INSA, Associação para a Promoção da Investigação em Saúde (Pró-INSA/INSARJ)

HMSP-ICT/0026/2011

Assessment of novel tools to predict vertebral fragility fractures and improve osteoporosis therapy decision-making: a validation study using a large cohort of Portuguese post-menopausal women
Helena Canhão
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

HMSP-ICT/0031/2011

Surgical Treatmentof of Peyronie´s Disease: Two New Grafts
Arlindo Jorge de Abreu Fonseca
Pró-INSA, Associação para a Promoção da Investigação em Saúde (Pró-INSA/INSARJ)

HMSP-ICT/0032/2011

Strategies to reduce ischemia/reperfusion injury of the liver graft by pre-transplant flushing/preservation pharmacological modulation.
Bruno Miguel Nogueira Sepodes
Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa)

HMSP-ICT/0033/2011

Development of dendritic cell-based vaccines with osteotropism for treatment of bone metastasis
Paula Alexandra Quintela Videira
Faculdade de Ciências Médicas (FCM/UNL)

HMSP-ICT/0034/2011

Autoregulation in intracerebral haemorrhage: parallel studies in patients and animal models
Maria Isabel de Sousa Rocha
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

HMSP-ICT/0035/2011

Single cell variation in mistranslation rates is responsible for phenotypic drug resistance
Manuel António Silva Santos
Universidade de Aveiro (UA)

HMSP-ICT/0036/2011

Ciliary membrane function in nasal poliposys
Susana Santos Lopes
Faculdade de Ciências Médicas (FCM/UNL)

HMSP-ICT/0041/2011

The identification of novel gene alterations that mediate risk of breast and/or prostate cancer in Portugal
Manuel António Rodrigues Teixeira
Instituto Português de Oncologia do Porto Francisco Gentil, EPE (IPO Porto)

HMSP-ICT/0044/2011

Development of antimicrobial agents to the treatment of multiple drug-resistant bacterial and fungal infections.
Maria Adelaide de Pinho Almeida
Universidade de Aveiro (UA)

HMSP-ICT/0045/2011

Systematic exploration and modeling of T-cell pathology in human Systemic Lupus Erythematosus
Constantin Fesel
Fundação Calouste Gulbenkian (FCG)

HMSP-ICT/0048/2011

Development of anti-cancer interfering RNAs in AAV vectors to treat human basal-like breast cancer
Paula Marques Alves
Instituto de Biologia Experimental e Tecnológica (IBET)

HMSP-ICT/0050/2011

Developing novel therapeutic applications for cancers with deregulated mTOR and metabolic activity (Basic and translational developments)
Ana Paula Soares Dias Ferreira
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

HMSP-ICT/0051/2011

Unraveling the role of Sirtuin 3 in mitochondrial metabolic control: implications in Parkinson's disease
Sandra Morais Cardoso
Centro de Neurociências e Biologia Celular (CNBC/UC)

HMSP-ICT/0054/2011

Novel approaches in sensory rehabilitation: expanding the visual field in people with visual loss
Miguel de Sá e Sousa de Castelo Branco
Universidade de Coimbra (UC)

HMSP-ICT/0056/2011

Clinical and therapeutic implications of N-RAS activation in colorectal cancers
Raquel Seruca
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

HMSP-ICT/0061/2011

Dissecting the leukemic niche: tumor cell growth versus immune surveillance in the bone marrow
Bruno Miguel de Carvalho Silva Santos
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

HMSP-ICT/0062/2011

Impact of Treatment Modality on Vascular Properties in Coarctation of the Aorta
José Diogo Ramalho Ortigão Ferreira Martins
Unidade Local de Saúde de São José E.P.E. (ULS)

HMSP-ICT/0063/2011

Novel Approaches to Understanding and Management of Breast Cancer Brain Metastases
Fatima Cardoso
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)