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R&D Projects

Biomedicine Evaluation Panel - 2012

Evaluation

Abhay Pandit
National University of Ireland, Galway, Ireland
Francesc Villarroya
Facultat de Biologia - Barcelona, Spain
Gabriel Capellá
L´Hospitalet de Llobergat, Barcelona, Spain
Geert Martens
Vrije Universiteit Brussel (VUB), Brussels, Belgium
Humphrey Hodgson
London Medical School, UCL, United Kingdom
Juan Carlos Leza
Universidad Complutense Madrid/ UCM, Spain
Lionel Ginsberg
Royal Free Hospital, UCL, United Kingdom
Mario Clerici
University of Milano, Italy
Reinhard Fässler
International Max Planck Research School (IMPRS), Munique, Germany
Stefan Imreh
Karolinska Institutet - Stockholm, Sweden

Projects assigned

FCT-ANR/BIM-ONC/0003/2012

Gain and loss of intestinal identity in pathological settings: the Bmp-Cdx2 axis.
Rita Henriques Pinto de Barros
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

FCT-ANR/BIM-ONC/0010/2012

Glycosylation of epidermal growth factor receptor as a novel marker for anti-EGFR therapies in colorectal cancer
Celso Albuquerque Reis
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

FCT-ANR/BIM-MEC/0077/2012

The role of Rac1b and cytokines signalling in Inflammatory Bowel Disease
Peter Jordan
Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa)

FCT-ANR/BIM-MEC/0114/2012

Novel biomarkers for diagnosis of spondyoarthrithis using epigenetic "signatures"
Alexandra Moreira
Instituto de Biologia Molecular e Celular (IBMC/UP)

FCT-ANR/BIM-MEC/0191/2012

Reticulum/mitochondria cross talk impairment in Alzheimer's and prion diseases
Cláudia Maria Fragão Pereira
Centro de Neurociências e Biologia Celular (CNBC/UC)

FCT-ANR/BIM-MEC/0197/2012

Interconnections between chromatin, transcription and post-transcriptional events in normal and malignant immune T cells
Maria Carmo-Fonseca
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

FCT-ANR/BIM-MEC/0208/2012

Genetics of host malaria resistance: from mice to humans
CARLOS AUGUSTO GOMES BARBOSA DA PENHA GONÇALVES
Fundação Calouste Gulbenkian (FCG)

FCT-ANR/BIM-MEC/0247/2012

MicroRNAs in monocytes, path for promising targets against rheumatic disorders
João Eurico Cortez Cabral da Fonseca
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

FCT-ANR/BIM-MET/0024/2012

Berries Driven Polyphenols for Cardioprotection
Maria Cláudia Nunes dos Santos
Instituto de Biologia Experimental e Tecnológica (IBET)

FCT-ANR/BIM-MED/0033/2012

Bio-Resorption of Polymer Composite Based Scaffolds for Bone Reconstruction
Paula Alexandrina de Aguiar Pereira Marques
Universidade de Aveiro (UA)

FCT-ANR/BIM-MED/0123/2012

CardiON - The Ontogeny of Cardiac (Re)Genesis
Perpetua Pinto do Ó
Instituto Nacional de Engenharia Biomédica - INEB Univ. Porto (INEB Porto)

PTDC/BIM-ONC/0007/2012

CDX2 regulation by MEX3A - A novel RNA-mediated regulatory mechanism in intestinal differentiation and carcinogenesis
Raquel Maria da Silva Graça Almeida
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-ONC/0021/2012

NK cell-based adoptive therapy targeting human bladder cancer stem cells: impact on tumor progression using an humanized orthotopic animal model
Célia Maria Freitas Gomes
Universidade de Coimbra (UC)

PTDC/BIM-ONC/0042/2012

Response an Electronic Health Patient Information System for Radiation Therapy Support and Radiobiological Research
Brígida Costa Ferreira
Universidade de Aveiro (UA)

PTDC/BIM-ONC/0075/2012

Mono and Bispecific antibodies for targeted cancer therapy: elucidating the cross-talk between Notch and other major breast cancer pathways.
Ana Barbas
Instituto de Biologia Experimental e Tecnológica (IBET)

PTDC/BIM-ONC/0210/2012

Locked Nucleic Acids as a novel therapeutic approach for prostate cancer.
Helena Margarida Guerra Pinheiro Vieira Reis
Associação do Instituto Superior Técnico para a Investigação e o Desenvolvimento (IST-ID)

PTDC/BIM-ONC/0257/2012

miR-143, miR-145 and miR-21 as therapeutic tools in colon cancer - anticancer activity, drug sensitization, and targeted delivery
Pedro Borralho
Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa)

PTDC/BIM-ONC/0261/2012

Molecular characterization of myelodysplastic syndromes - prognostic and therapeutic implications
Ana Bela Sarmento Ribeiro
Universidade de Coimbra (UC)

PTDC/BIM-ONC/0323/2012

Dissecting the link between aneuploidy and genomic instability in humans - implications for cancer
Elsa Logarinho
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-ONC/0377/2012

Targeted therapies against prostate cancer stem cells
PEDRO JORGE GOMES TEODÓSIO CASTELO BRANCO
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-ONC/0384/2012

SETD2 mediates a novel tumor suppressor mechanism that is misregulated in clear cell renal carcinoma
SÉRGIO ALEXANDRE FERNANDES DE ALMEIDA
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-ONC/0456/2012

The role of annexin A2 in reactive oxygen species (ROS)dependent signaling
Patrícia Alexandra Saraiva Madureira
Universidade do Algarve (UAlg)

PTDC/BIM-ONC/0566/2012

Role of interference with B cell terminal differentiation in lymphoma development
Dinis Pedro Parente Calado
Fundação Calouste Gulbenkian (FCG)

PTDC/BIM-ONC/0573/2012

The role of KRAS mutations signalling in autophagy regulation in colorectal carcinoma: towards identification of new therapeutic targets.
Ana Preto
Universidade do Minho (UM)

PTDC/BIM-ONC/0594/2012

An approach to thyroid cancer targeted-therapy using transgenic zebrafish as a model.
Ana Paula Soares Dias Ferreira
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-ONC/0697/2012

Role of monocarboxylate transporters (MCTs) in the crosstalk between oncogenic signalling and metabolic remodelling in colorectal carcinoma
Maria de Fátima Monginho Baltazar
Universidade do Minho (UM)

PTDC/BIM-ONC/0783/2012

Implications of Claspin mutations in the maintenance of cell homeostasis, oncogenesis and response to chemotherapy
Teresa Maria Caldeira Martins
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-ONC/0816/2012

New therapeutic targets in head and neck carcinomas - A comparative study.
Maria Celeste Fernandes Lopes
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-ONC/0914/2012

Uncovering the genetic basis of familial thyroid cancer by whole-exome sequencing
Branca Maria Prudêncio Limón Cavaco
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-ONC/0926/2012

Studying the aggressiveness of hepatocellular carcinoma
LUÍS FILIPE FORTADO SOARES TOMÉ
Universidade de Coimbra (UC)

PTDC/BIM-ONC/0967/2012

Influence of HOXA9 Oncogene in the Response of Glioblastoma to Chemotherapy: Mechanisms of Resistance and Novel Therapeutic Strategies
Bruno Costa
Universidade do Minho (UM)

PTDC/BIM-ONC/0975/2012

OVARIAN CLEAR CELL CARCINOMA METABOLOME AS A PLATFORM TO DISCOVER SPECIFIC AND MORE EFFECTIVE THERAPEUTIC TARGETS
Jacinta Serpa
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-ONC/0978/2012

Light and Radiotherapy for cancer disease
Maria Filomena Rabaça Roque Botelho
Universidade de Coimbra (UC)

PTDC/BIM-ONC/1120/2012

Monocarboxylate transporters (MCTs) as putative therapeutic targets in acute myeloid leukaemia (AML)
Jacinta Serpa
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-ONC/1128/2012

New therapeutic strategies for melanoma: Evaluation of endoxifen combined action with glutamate antagonists
José Barata Antunes Custódio
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-ONC/1156/2012

Epigenetic effects of phytochemicals in osteosarcoma cell lines: global and specific DNA methylation
José Miguel Pimenta Ferreira de Oliveira
Universidade de Aveiro (UA)

PTDC/BIM-ONC/1164/2012

Cell cycle and cancer biology - the molecular function of tumor supressors Mob1, LZTS1 and LZTS1
ÁLVARO AUGUSTO MARQUES TAVARES
Universidade do Algarve (UAlg)

PTDC/BIM-ONC/1242/2012

Cerebrospinal fluid metabolome: an instructive niche for CNS metastasis
Tânia Gilot Mendes de Carvalho
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-ONC/1254/2012

The relationship between mitochondria and nucleus in cancer cells: A Lipid talking
Romeu António Videira
Universidade de Trás-os-Montes e Alto Douro (UTAD)

PTDC/BIM-ONC/1277/2012

The Myeloid Block: Resistance to Therapy and Disease Progression in Chronic Myeloid Leukemia
António Sebastião Rodrigues
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-ONC/1283/2012

MicroRNAs profile expression in Hepatocellular Carcinoma: Potential prognostic and therapeutic value
Jose Manuel Borges Nascimento Costa
Universidade de Coimbra (UC)

PTDC/BIM-ONC/1298/2012

Role of the dac/DACH1 tumor suppressor in inactivating the Yki/YAP/TAZ oncogenes in Drosophila and human.
Florence Janody
Fundação Calouste Gulbenkian (FCG)

PTDC/BIM-ONC/1338/2012

Cis-regulation of somatic mutations in breast and ovarian cancers
Ana Teresa Luís Lopes Maia
Universidade do Algarve (UAlg)

PTDC/BIM-ONC/1435/2012

SMYD3 and MLL as modulators of Histone 3 Lysine 4 Trimethylation and their role in Prostate Carcinogenesis
Rui Manuel Ferreira Henrique
Instituto Português de Oncologia do Porto Francisco Gentil, EPE (IPO Porto)

PTDC/BIM-ONC/1436/2012

Is lipofilling safe, when used in brest reconstruction in oncologic cases? Evaluation of the tumorigenic potential of adipose stem cells
Alexandrina Maria Ferreira dos Santos Pinto Mendes
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-ONC/1548/2012

Do miRNAs and TAL1 crosstalk? New insights into the regulation and function of a major T-cell oncogene
João Pedro Taborda Barata
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-ONC/1611/2012

Epigenetic modification in myeloproliferative neoplasms: role in pathophysiology and therapeutic potential.
António Medina de Almeida
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-ONC/1643/2012

3D cancer model system for the in vitro study of patophysiology and drug screening
Albino Martins
Universidade do Minho (UM)

PTDC/BIM-MEC/0058/2012

Identification of the molecular etiology of atherogenesis
Otília Vieira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/0098/2012

Glucose and lipid metabolism - the role of immunosuppressive agents
EUGÉNIA MARIA LOURENÇO DE CARVALHO
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/0184/2012

Bone loss in Rheumatoid Arthritis - modulation of Wnt/beta-catenin pathway
Joana Ribeiro Caetano Lopes
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/0203/2012

Modeling of T-cell pathology in human SLE and its compensation in unaffected relatives by mRNomics
Constantin Fesel
Fundação Calouste Gulbenkian (FCG)

PTDC/BIM-MEC/0246/2012

Unravelling the role of adenosine on glucose homeostasis and insulin action
SÍLVIA MARGARIDA VILARES SANTOS CONDE
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MEC/0260/2012

Oxidative Stress vs Epigenetics - Role in susceptibility and therapy response in hemato-oncology
Ana Bela Sarmento Ribeiro
Universidade de Coimbra (UC)

PTDC/BIM-MEC/0277/2012

Physiological Determinants of Nasal Polyposis
NUNO MANUEL BARREIROS NEUPARTH
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MEC/0278/2012

From brain to liver disease: seeking in mitochondrial metabolism new therapeutic strategies for a good old HDACi
Margarida Maria Fernandes Baptista e Silva
Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa)

PTDC/BIM-MEC/0296/2012

Characterization of Endocrine (adrenal and thyroid) functional status and Immunological profile on Haemorragic Shock in a Rat Experimental Model
MARIA MANUELA GRAVE RODEIA ESPADA NIZA
Faculdade de Medicina Veterinária (FMV/ULisboa)

PTDC/BIM-MEC/0326/2012

Function of Arl13b in membrane traffic and primary cilium biology
Duarte Barral
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MEC/0337/2012

Mechanisms of nonsense-mediated mRNA decay and suppression therapy as a novel approach to treat genetic diseases
Luísa Romão
Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa)

PTDC/BIM-MEC/0379/2012

Functional study of risk factors identified in several mechanisms associated with migraine susceptibility
Carolina Lemos
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-MEC/0388/2012

Investigation of type 1 Diabetes Mellitus as risk factor for secondary osteoporosis
José Américo Almeida de Brito
Egas Moniz - Cooperativa de Ensino Superior, CRL (CESEM)

PTDC/BIM-MEC/0408/2012

A fase cerebral da Doença do Sono: papel dos tripanosomas no ritmo circadiano de ratinho
Luisa M Figueiredo
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/0423/2012

The relationship between nutrient uptake by first trimester human trophoblasts and placentation: relevance in intrauterine growth restriction
Fátima Martel
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/0424/2012

Unravelling hippocampal neuronal alterations underlying cognitive impairment in a model of insulin resistance
Joana Margarida Navalho Gaspar
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MEC/0443/2012

Regulation of E-cadherin stability at the Plasma Membrane: molecular determinants and functional impact in disease
Joana Correia
Universidade de Coimbra (UC)

PTDC/BIM-MEC/0444/2012

S100B in central nervous system demyelination/remyelination: a cytoskeletal perspective
Adelaide Fernandes
Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa)

PTDC/BIM-MEC/0450/2012

The role of epigenetic mechanisms in CAG repeat instability and as modifiers in Huntington's disease
Isabel Alonso
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-MEC/0453/2012

Reverse ventricular remodeling in idiopathic dilated cardiomyopathy
Sandra Amorim
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/0474/2012

A new strategy for therapeutic neovascularization: Low doses of Ionizing radiation
Susana Constantino Rosa Santos
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/0584/2012

Defective autophagy in Crohn´s disease - making the way for Mycobacterium avium subsp. paratuberculosis persistence?
Amélia Maria Marques da Silva Rodrigues Sarmento Assunção
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-MEC/0595/2012

Evaluation of markers of renin-angiotensin system and oxidative stress in heart failure: importance for risk stratification and therapeutic management.
António Albino-Teixeira
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/0607/2012

Antibodies towards high density lipoprotein (HDL) are associated with an increase in atherosclerosis risk due to an inhibition of the protective functions of HDL
José Delgado Alves
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MEC/0628/2012

Hematopoietic failure and redox signaling in Fanconi Anemia (FA): searching for causes and prevention against progression of the disease
Maria Beatriz Beça Gonçalves Porto e Vasconcelos
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/BIM-MEC/0629/2012

Unravelling the importance of signal transduction pathways for DYT1 dystonia.
Sandra Maria Tavares da Costa Rebelo
Universidade de Aveiro (UA)

PTDC/BIM-MEC/0638/2012

Role of androgens in the regulation of the umbilical arterial tonus and in preeclampsia
Ignacio Verde
Universidade da Beira Interior (UBI)

PTDC/BIM-MEC/0650/2012

Portuguese study of familial dilated cardiomyopathies
Elisabete Martins
Sociedade Portuguesa de Cardiologia (SPC)

PTDC/BIM-MEC/0657/2012

Biomarkers in Calcium Pyrophosphate Deposition Arthropathy (CPPD-CC) . A combined approach.
Jacome Bruges Armas
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-MEC/0669/2012

The role of Autophagy in the Pathophysiology of Lysosomal Storage Diseases
Sandra Catarina da Conceição Alves
Instituto Nacional de Saúde Dr. Ricardo Jorge (INSARJ)

PTDC/BIM-MEC/0672/2012

Aged female reproduction: role of redox imbalance in placental bed diseases.
Elisabete Silva
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/0724/2012

The anthracycline epirubicin triggers an ATM-dependent protective response against severe sepsis
LUÍS FILIPE FERREIRA MOITA
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/0740/2012

Endoplasmic reticulum stress, impaired insulin signaling and mitochondrial dysfunction: a deadly triode in Type 1 Diabetes Mellitus-associated neurogeneration
Cláudia Maria Fragão Pereira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/0756/2012

Mechanisms of natriuretic peptide system dysfunction in nephrotic syndrome: relationship with renal dopaminergic system activity and vitamin D3 deficiency
Manuel Pestana
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/0765/2012

Mechanisms of adaptation to centrosome amplification in epithelial cells
Susana Godinho
Fundação Calouste Gulbenkian (FCG)

PTDC/BIM-MEC/0780/2012

A new perspective to study the role of iron metabolism in atherogenesis
LUCIANA MARIA GONÇALVES DA COSTA
Pró-INSA, Associação para a Promoção da Investigação em Saúde (Pró-INSA/INSARJ)

PTDC/BIM-MEC/0789/2012

Unveiling the role of experimental malaria infection during implantation and pre-term
Carlos Eduardo Tadokoro
Fundação Calouste Gulbenkian (FCG)

PTDC/BIM-MEC/0798/2012

Unity is strength? Studing the impact of endothelial methylation imbalance on oxidative balance: implications for homocysteine-related vascular disease.
Maria Rita M A Azevedo e Castro
Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa)

PTDC/BIM-MEC/0808/2012

I-GASP: an Integrative Genetic and genomics Approach to primary Spontaneous Pneumothorax susceptibility
Ana Sofia Simões Domingues de Almeida Oliveira
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/0817/2012

IRONBONE_Identification of molecular players in iron-related osteoarthritis: Hereditary Hemochromatosis as a case study
Leonor Cancela
Centro de Ciências do Mar (CCMar)

PTDC/BIM-MEC/0855/2012

Inhibition of chemotherapy-induced EMT for overcoming acquired drug resistance and tumour relapse
Gabriela Martinho de Almeida
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-MEC/0873/2012

Aiming at miR-21 and bile acid-activated receptors in non-alcoholic fatty liver disease pathogenesis: two bullets for one murder?
Rui E Castro
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/BIM-MEC/0874/2012

RANK signaling in leukemia microenvironmental cells: function and molecular mechanisms
Nuno Alexandre Pinto Rodrigues dos Santos
Universidade do Algarve (UAlg)

PTDC/BIM-MEC/0883/2012

Structure-function studies in metalloenzymes related to inborn errors of metabolism: molecular basis for classical homocystinuria and galactosemia
João Filipe Bogalho Vicente
Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa)

PTDC/BIM-MEC/0954/2012

Proteins of pancreatic zymogen granules as novel tools in molecular cell biology and medicine
Michael Schrader
Universidade de Aveiro (UA)

PTDC/BIM-MEC/0966/2012

Phosphorylation pathways involved in huntingtin oligomerization and toxicity: in vitro and in vivo studies
Federico Herrera
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/0989/2012

An integrative genomics approach to unravel causal variants in severe spermatogenic impairment
Alexandra Manuel Ferreira Lopes
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-MEC/1010/2012

Refining the role of microRNAs as co-regulators of branched chain alpha-ketoacid dehydrogenase complex
Maria Sofia Ferreira Pacheco Quental
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-MEC/1017/2012

Dissecting the molecular mechanisms of EPC response to myocardial ischemia in diabetes: from bench to bedside
Rosa Cristina S Fernandes
Universidade de Coimbra (UC)

PTDC/BIM-MEC/1035/2012

Bone to Brain: Cytokines as mediators in the feedback loop
Meriem Lamghari Moubarrad
Instituto Nacional de Engenharia Biomédica - INEB Univ. Porto (INEB Porto)

PTDC/BIM-MEC/1051/2012

Study of ulcerogenic Helicobacter pylori strains isolated from children: a contribution to get insight the pathogenesis of the peptic ulcer in pediatrics.
Mónica Oleastro
Pró-INSA, Associação para a Promoção da Investigação em Saúde (Pró-INSA/INSARJ)

PTDC/BIM-MEC/1055/2012

The relationship between butyrate and breast cancer resistance protein: relevance in colorectal cancer
Fátima Martel
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/1070/2012

Neural correlates of executive dysfunction and stereotypical behaviour in autism: a search for an unifying mechanism
Guiomar Gonçalves de Oliveira
Universidade de Coimbra (UC)

PTDC/BIM-MEC/1080/2012

T-cell repertoire and clonal size dynamics and antigenic determinant spreading in Systemic Lupus Erythematosus
Constantin Fesel
Fundação Calouste Gulbenkian (FCG)

PTDC/BIM-MEC/1095/2012

Quantitative method for Diabetic Macular Edema (DME) treatment response patterns identification
José Paulo Domingues
Universidade de Coimbra (UC)

PTDC/BIM-MEC/1117/2012

Stressed heart: understanding stress-induced heart disease
JOÃO JOSÉ FERNANDES CARDOSO DE ARAÚJO CERQUEIRA
Universidade do Minho (UM)

PTDC/BIM-MEC/1160/2012

RENAL OSTEODYSTROPHY IN PREDIALYSIS PATIENTS - DIAGNOSTIC AND THERAPEUTIC IMPLICATIONS
João Miguel Machado Dória Frazão
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/1165/2012

Chronic Alcohol Consumption and Hypertension: The role of renin-angiotensin system and nitric oxide
Sandra Leal
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/1168/2012

New insigths into the mechanism of vascular calcification in chronic kidney disease (CKD): the role of GRP
Carla Alexandra São Bento Viegas
Centro de Ciências do Mar (CCMar)

PTDC/BIM-MEC/1172/2012

Interplay between Abeta and Ca2+ in Alzheimer's disease, TUDCA and neuroprotection
Joana Estêvão de Matos
Fundação da Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa (FFCT/FCT/UNL)

PTDC/BIM-MEC/1177/2012

Nano inflammation: How inflammation early affects bone properties at the onset of rheumatoid arthritis.
João Eurico Cortez Cabral da Fonseca
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/1198/2012

GENIA: GENetics of Intracranial Aneurysms
Ana Sofia Simões Domingues de Almeida Oliveira
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/1286/2012

Identification and characterization of genes required for photoreceptor degeneration caused by ER stress
Pedro Manuel Dias Neto Domingos
ITQB NOVA - Instituto de Tecnologia Química e Biológica António Xavier (ITQB NOVA/UNL)

PTDC/BIM-MEC/1350/2012

Atherogenesis and osteoporosis common underlying mechanisms
Maria Jose Santos
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/1383/2012

Multiples faces, one end: PTEN in neuroendocrine tumours.
Ana Paula Soares Dias Ferreira
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-MEC/1385/2012

Using the fundamentals of phase transitions to tackle the problem of amyloid formation
Pedro Miguel Martins
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/BIM-MEC/1421/2012

Human Endogenous retrovirus as biomarkers for renal cell carcinoma: the regulatory role of circulating microRNAs and associated genetic variants
RUI Manuel de MEDEIROS Melo Silva MEDEIROS
Instituto Português de Oncologia do Porto Francisco Gentil, EPE (IPO Porto)

PTDC/BIM-MEC/1462/2012

From Human Proteomics to Development of Therapeutic Targets for Lung Hypoplasia
Jorge Manuel Nunes Correia Pinto
Universidade do Minho (UM)

PTDC/BIM-MEC/1468/2012

Novel therapies for Rheumatoid Arthritis based on the simultaneous targeting of IL-1β and TNF
LUÍS FILIPE FERREIRA MOITA
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MEC/1488/2012

Adenosine - a bridge between the nervous and immune systems focusing on autoimmune Myasthenia Gravis
Laura Oliveira
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/BIM-MEC/1497/2012

UCP2 a new molecular target of SIRT3: Relevance in Alzheimer's disease
Sandra Morais Cardoso
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/1533/2012

Purinergic interplay between fibroblasts and cardiomyocytes as a target for pharmacological intervention in cardiac remodeling
Paulo Correia de Sá
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/BIM-MEC/1569/2012

Neurogenic effects on SLE heterogeneity evaluated by improved clinical evaluation
CARLOS ALBERTO DA SILVA E VASCONCELOS
Centro Hospitalar Universitário do Porto (CHP/MS)

PTDC/BIM-MEC/1612/2012

On the role of purinergic system in an animal model of doxorubicin-induced cardiomyopathy - clinical relevance
Ana Patrícia Fontes de Sousa
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/BIM-MEC/1636/2012

How to build a model to increase safety of sacral nerve stimulation? An interdisciplinary research strategy
Maria Amélia Duarte Ferreira
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MEC/1811/2012

F.R.A.X.A. - FRAXopaties Research Applying X-omic Analyses
Isabel Maria Medeiros Marques
Instituto Nacional de Saúde Dr. Ricardo Jorge (INSARJ)

PTDC/BIM-MET/0027/2012

Neuroprotection mechanisms by food polyphenols: prophylactic possibilities for neurodegeneration
Rui Fernando Marques da Silva
Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa)

PTDC/BIM-MET/0044/2012

Interplay between histone deacetylases and cholesterol metabolism - emerging role in neurodegeneration
Elsa Margarida Teixeira Rodrigues
Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa)

PTDC/BIM-MET/0045/2012

A new twist on diabetes: The bile acid-hypothalamus link as key therapeutic strategy
Carlos Palmeira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MET/0294/2012

The fate of the fat: role of hypoxia and Neuropeptide Y
Joana Salgado
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MET/0425/2012

Functional Foods/Nutraceuticals: a new approach to the prevention of intestinal differentiation induced by Helicobacter pylori
António José Murinello de Sousa Guerreiro
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MET/0477/2012

Role of melanocortin system in human adipocyte biology
Alexandra Maria Monteiro Gouveia
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MET/0486/2012

CD26/DPP4 in Fatty Liver Disease progression: inflammation impinges on dysmetabolism.
Maria Paula Borges de Lemos Macedo
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/BIM-MET/0521/2012

Endogeneous Cannabinoids as potential biomarkers in eating disorders
Maria Augusta Vieira Coelho
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-MET/0598/2012

IRON METABOLISM AND LYMPHOCYTE HOMEOSTASIS: implications to the pathogenesis of Hemochromatosis
Maria da Graça Beça Gonçalves Porto
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-MET/0870/2012

Polyphenolic nutraceutics system for oral delivery of resveratrol.
Ana Figueiras
Universidade de Coimbra (UC)

PTDC/BIM-MET/0878/2012

Assessment of the real risk associated to the intake of heterocyclic amines through consumption of fish subjected to different culinary treatments
Carlos Manuel Lourenço Cardoso
Instituto Português do Mar e da Atmosfera, I. P. (IPMA)

PTDC/BIM-MET/0893/2012

Terpene-based nutraceuticals: can they play a new role in the managment of Alzheimer´s disease?
Lígia Maria Salgueiro Silva Couto
Universidade de Coimbra (UC)

PTDC/BIM-MET/0922/2012

Olive oil polyphenols in the prevention of cardiovascular disease.
Fátima Paiva-Martins
Faculdade de Ciências da Universidade do Porto (FCUP/UP)

PTDC/BIM-MET/1021/2012

Neuroprotection and neuromodulation of dietary polyphenols.
Ana Faria
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MET/1337/2012

Bone Loss during Menopause - Role of Metabolic Failure and Antiosteoporetic Effects of Phytoestrogens
Maria Sancha de Jesus Vieira dos Santos
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MET/1380/2012

The best way to prepare tea: Optimizing health and senses.
Tânia Vanessa Santos de Almeida
Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa)

PTDC/BIM-MET/1408/2012

Exploiting the effects and molecular mechanisms of L-arginine on body fat reduction and obesity
JOSÉ ANTÓNIO MESTRE PRATES
Faculdade de Medicina Veterinária (FMV/ULisboa)

PTDC/BIM-MET/1512/2012

Lactate as a molecular sensor for enhancing mitochondrial power during exercise through sirtuin signaling?
Ignacio Vega Naredo
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MET/1536/2012

Estrogens in human obesity - influence on number, type and functional properties of inflammatory cell subtypes. Exploring the involvement of estrogen receptor alpha.
Maria do Rosário Barbosa Monteiro
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MET/1604/2012

Molecular profiling of AGRP neurons and hyperphagia
Ana Domingos
Fundação Calouste Gulbenkian (FCG)

PTDC/BIM-MET/1628/2012

MAJOR DETERMINANTS OF QUALITY OF HEALTH CARE IN CANCER: PATIENTS' NUTRITION AND BODY COMPOSITION MODULATE TREATMENTS' EFFICACY, QUALITY OF LIFE AND SURVIVAL?
Paula Ravasco
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MET/1641/2012

Insulin resistance and cannabinoid receptors: neither with them, nor without them?
Attila Köfalvi
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MET/1652/2012

Evaluation of endemic plants from Algarve for management of diabetes and hypertension
Isabel Maria Marques Saraiva de Carvalho
Universidade do Algarve (UAlg)

PTDC/BIM-MED/0165/2012

Microengineered hydrogels for improving the vascularization of dermal substitutes
Alexandra P Marques
Universidade do Minho (UM)

PTDC/BIM-MED/0251/2012

Driving Mitochondrial Effectors of Apoptosis Toward Neural Differentiation
SUSANA ZEFERINO SOLÁ DA CRUZ
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/BIM-MED/0352/2012

Translational regulation of human erythropoietin (EPO) by an upstream open reading frame (uORF) and its impact on myocardial ischemia
Luísa Romão
Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa)

PTDC/BIM-MED/0475/2012

GENERE - A new GENE therapy approach for the treatment of REtinal neovascularization
Gabriela Araújo da Silva
Universidade do Algarve (UAlg)

PTDC/BIM-MED/0773/2012

Study of the transcriptional network controlling the maintenance of pluripotency and survival of embryonic stem cells
José Bragança
Universidade do Algarve (UAlg)

PTDC/BIM-MED/0775/2012

Restoring neurogenesis in the hypothalamus by a pharmacological agent: new innovative therapeutic strategy in obesity
CLÁUDIA MARGARIDA GONÇALVES CAVADAS
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MED/1039/2012

ImmunoTEC - Immunogenic potential of adipose tissue- and starch-based tissue engineering constructs
Tírcia Susete Xavier Carlos Santos
Universidade do Minho (UM)

PTDC/BIM-MED/1063/2012

human Mesenchymal Stem Cells Chronobiology: evaluating the crosstalk between the Embryonic and Circadian Clocks
Isabel Maria Mestre Marques Palmeirim
Universidade do Algarve (UAlg)

PTDC/BIM-MED/1075/2012

Regulation of Cardiac Stem Cell proliferation and diferentiation by microRNAs
Luis Afonso Bras Simoes Rosario
Associação para Investigação e Desenvolvimento da Faculdade de Medicina (AIDFM/FM/ULisboa)

PTDC/BIM-MED/1135/2012

Exploring the Therapeutic Potential of Mesenchymal Stem Cells Derived from Human Pluripotent Stem Cells in Parkinson's Disease Regenerative Medicine
António José Braga Osório Gomes Salgado
Universidade do Minho (UM)

PTDC/BIM-MED/1141/2012

The endocannabinoid system in pathogenesis of dermal fibrosis
Jose Eduardo Ferreira Moura
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MED/1158/2012

Preclinical exploitation of biodegradable fibrous meshes using minimally invasive surgery.
Nuno Neves
Universidade do Minho (UM)

PTDC/BIM-MED/1375/2012

Uncovering cellular mechanisms of spinal cord regeneration in zebrafish and their modulation with aging
Maria Leonor Tavares Saúde
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/BIM-MED/1390/2012

A new controlled release system for the treatment of localized psoriasis lesions
Marta Luisa Sousa Dias Alves da Silva
Universidade do Minho (UM)

PTDC/BIM-MED/1442/2012

Relevance of P2 purinoceptors on hematopoietic progenitor cells regulating osteogenic differentiation of human mesenchymal stem cells
Maria Adelina Coelho Ribeiro Costa
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/BIM-MED/1454/2012

Human Meniscus Regeneration Using Tissue Engineering and Regenerative Medicine Strategies
Joaquim Miguel Antunes Correia de Oliveira
Universidade do Minho (UM)

EXPL/BIM-ONC/0197/2012

Metastasis as a cell strategy to search for phosphorus to mantain high growth rate
Maria José Caramujo Rocha de Carvalho
Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa)

EXPL/BIM-ONC/0209/2012

Expression of monocarboxylate transporter 1 (MCT1) in human tumours: a double-edged sword?
Céline Pinheiro
Universidade do Minho (UM)

EXPL/BIM-ONC/0228/2012

Amniotic membrane: a new and fascinating application in oncology?
Carlos Manuel Domingues Freire de Oliveira
Universidade de Coimbra (UC)

EXPL/BIM-ONC/0299/2012

Is modulation of LBK1-AMPK pathway a good strategy for acute leukemia therapy?
isabel maria da silva castro
Universidade do Minho (UM)

EXPL/BIM-ONC/0321/2012

Genetic variants in the vitamin D pathway and risk of thyroid cancer
Manuel Lemos
Universidade da Beira Interior (UBI)

EXPL/BIM-ONC/0429/2012

SEARCHING FOR NOVEL PROTEINS INVOLVED IN COLORECTAL CANCER
ALEXANDRE RUI DE SAMPAIO TEIXEIRA
Faculdade de Ciências Médicas (FCM/UNL)

EXPL/BIM-ONC/0479/2012

Learning from the embryo: Assessing early embryonic T gene - Brachyury - impact in human tumorigenesis
RUI MANUEL VIEIRA REIS
Universidade do Minho (UM)

EXPL/BIM-ONC/0490/2012

Development of a novel adoptive cell therapy for leukemia: characterization and optimization of gamma-delta T lymphocytes for clinical application.
Bruno Miguel de Carvalho Silva Santos
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

EXPL/BIM-ONC/0550/2012

Exploring ETS oncogenetic mechanisms across germ layer boundaries may reveal stem-cell-like features shared by phenotypicaly diverse neoplasias
Manuel António Rodrigues Teixeira
Instituto Português de Oncologia do Porto Francisco Gentil, EPE (IPO Porto)

EXPL/BIM-ONC/0582/2012

Role of H2O2 produced by tumor microenvironment
Carla Sofia Fernandes do Amaral Real Afonso
Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa)

EXPL/BIM-ONC/0598/2012

Seeking a missing link: effects of environmental stimuli on Hippo tumor suppressor signaling
Takashi Koyama
Fundação Calouste Gulbenkian (FCG)

EXPL/BIM-ONC/0675/2012

How to tame a neoplasia - Epigenetic changes and hormonal microenviroment in endometrial cancer.
CARLA MARIA MAGNO BARTOSCH
Instituto Português de Oncologia do Porto Francisco Gentil, EPE (IPO Porto)

EXPL/BIM-ONC/0677/2012

Peptide-Mediated siRNA Delivery targeting the BCR-ABL Fusion Gene - Chronic Myeloid Leukemia Molecular Therapy.
Ana Salomé Rocha do Nascimento Veiga
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

EXPL/BIM-MEC/0015/2012

mi(RNA)tochondria: A role for miRNA as the initiators of metabolic disease?
Anabela Pinto Rolo
Centro de Neurociências e Biologia Celular (CNBC/UC)

EXPL/BIM-MEC/0034/2012

Deciphering the role of GDF15 in deregulated iron metabolism in anemias of ineffective erythropoiesis
Rute Isabel Paulo Martins
Pró-INSA, Associação para a Promoção da Investigação em Saúde (Pró-INSA/INSARJ)

EXPL/BIM-MEC/0115/2012

A Molecular Imaging Approach to Cystic Fibrosis
Filipa Fernandes Mendes
Associação do Instituto Superior Técnico para a Investigação e o Desenvolvimento (IST-ID)

EXPL/BIM-MEC/0139/2012

B1 cell dysfunctions in type 1 diabetes patients: molecular mechanisms underlying pancreatic beta cell stress
Nádia Cristina Varela da Silva Duarte
Fundação Calouste Gulbenkian (FCG)

EXPL/BIM-MEC/0205/2012

CD6 in B-CLL: exploring its role and (potential) usefulness.
Mafalda Maria dos Santos Pinto
Instituto de Biologia Molecular e Celular (IBMC/UP)

EXPL/BIM-MEC/0232/2012

Mechanisms of pathogenesis in Machado-Joseph Disease: ataxin-2 aberrant interaction with ataxin-3?
Clevio David Rodrigues Nobrega
Centro de Neurociências e Biologia Celular (CNBC/UC)

EXPL/BIM-MEC/0285/2012

Role of adenosine A2A receptors in suicide.
Paula Margarida Gomes Canas
Centro de Neurociências e Biologia Celular (CNBC/UC)

EXPL/BIM-MEC/0286/2012

Protective effect of exercise training in pulmonary arterial hypertension: seric and urinary proteomic profile
Tiago Alexandre Henriques Coelho
Faculdade de Medicina da Universidade do Porto (FM/UP)

EXPL/BIM-MEC/0430/2012

Unravelling LRRK2 role on mitochondrial (dys)function in Parkinson's disease
Ana Esteves
Centro de Neurociências e Biologia Celular (CNBC/UC)

EXPL/BIM-MEC/0435/2012

Identification of molecular mechanisms underlying human maternal anneuploidies
Sofia Dória Principe dos Santos Cerveira
Faculdade de Medicina da Universidade do Porto (FM/UP)

EXPL/BIM-MEC/0457/2012

The glyco-OralOme in Peri-implantitis
Marlene Barros
Universidade Católica Portuguesa (UCP)

EXPL/BIM-MEC/0498/2012

Prions infectivity during neural differentiation of embryonic stem cells analysed by proteomics
Joana Isabel Araújo de Macedo
Universidade do Algarve (UAlg)

EXPL/BIM-MEC/0534/2012

Chronic cardiomyopathy induced by doxorubicin and trastuzumab: unraveling its underlying mechanisms and renin angiotensin system pathophysiological role
Paulo Manuel Castro Chaves
Faculdade de Medicina da Universidade do Porto (FM/UP)

EXPL/BIM-MEC/0558/2012

The role of a novel membrane protein in the pathophysiology of Cystic Fibrosis
Luka Alexander Clarke
Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa)

EXPL/BIM-MEC/0580/2012

Is Lipocalin 2 a new modulator in multiple sclerosis?
Fernanda Cristina Gomes de Sousa Marques
Universidade do Minho (UM)

EXPL/BIM-MEC/0642/2012

The role of genetic polymorphism of the POR gene in the severity of malaria
Michel Kranendonk
Faculdade de Ciências Médicas (FCM/UNL)

EXPL/BIM-MET/0101/2012

Epigenetics and obesity: a DNA methylation analysis in buccal cells
Licínio Manuel Mendes Manco
Universidade de Coimbra (UC)

EXPL/BIM-MET/0112/2012

Red Wine Polyphenols as a novel antimicrobial agents: molecular mechanisms involved in the protection against pathogenic intestinal bacteria.
Carla Maria dos Santos Nunes
Centro de Neurociências e Biologia Celular (CNBC/UC)

EXPL/BIM-MET/0382/2012

The Metabolome of Mitochondrial Dysfunction in Cancer
Jorge Filipe de Almeida Vieira Lima
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

EXPL/BIM-MET/0704/2012

Modulation of endothelial and inducible nitric oxide synthases and arginase 1 polymorphisms effects on endothelial dysfunction by a nutraceutical and a functional diet therapy: A nutrigenetic intervention
ligia maria lacerda barbosa braga
Associação para Investigação e Desenvolvimento da Faculdade de Medicina (AIDFM/FM/ULisboa)

EXPL/BIM-MED/0167/2012

Reversion of the effect of osteonecrosis of the jaw by bisphosphonates: a new biomaterials approach
Manuel Marques Ferreira
Universidade de Coimbra (UC)

EXPL/BIM-MED/0284/2012

Tissue engineering of blood vessels using polyvinyl alcohol (PVA) constructs: in vitro and in vivo studies
Ana Lúcia Emidia de Jesus Luís
Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares - Porto (ICETA-Porto/ICETA)

EXPL/BIM-MED/0359/2012

Biomimetic strategies to enhance flexor tendon regeneration
Márcia Teresa Silva Rodrigues
Universidade do Minho (UM)

EXPL/BIM-MED/0599/2012

Regulation of embryonic stem cells pluripotency through F-box activity
Gisela Sofia Mendes Machado de Oliveira
Universidade do Algarve (UAlg)

EXPL/BIM-MED/0711/2012

Endothelial progenitor cells in neoangiogenesis of Acute Ischemic Stroke
Luis Augusto Salgueiro Cunha
Centro de Neurociências e Biologia Celular (CNBC/UC)

RECI/BIM-ONC/0010/2012

Novel proteomics strategies for oncobiology research
Hugo Alexandre Carvalho Pinheiro Osório
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

RECI/BIM-ONC/0119/2012

Targeting Subcellular Protein Localization - A Pathway to Anticancer Therapy
Wolfgang Link
Universidade do Algarve (UAlg)

RECI/BIM-ONC/0201/2012

A Pilot Study of Tumor-Derived Microvesicles and Bone Marrow Progenitor Cells as Diagnostic and Prognostic Biomarkers in Advanced (ABC) and Inflammatory Breast Cancers (IBC) Patients
Fatima Cardoso
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

RECI/BIM-MEC/0085/2012

Plataforma de Metabolómica Funcional no CNC-UC
Rui de Albuquerque Carvalho
Centro de Neurociências e Biologia Celular (CNBC/UC)

RECI/BIM-MEC/0134/2012

BioCIISA - Laboratory animals for interdisciplinary research
Luis Manuel Morgado Tavares
Faculdade de Medicina Veterinária (FMV/ULisboa)

RECI/BIM-MEC/0161/2012

Animal models of human disease: refinement of strategies and implementation of new technologies
Joana Margarida da Silva Marques
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

RECI/BIM-MEC/0188/2012

Confocal microscopy in the drug discovery and development process: from target identification to drug delivery and therapeutic efficacy
Maria Alexandra de Oliveira Silva Braga Pedreira de Brito
Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa)

RECI/BIM-MEC/0202/2012

Elucidation of the etiopathogenesis of human disorders by means of animal models
Jorge Cândido Pinheiro da Costa Machado
Instituto Nacional de Saúde Dr. Ricardo Jorge (INSARJ)

RECI/BIM-MED/0172/2012

Differentiation of Human Embryonic Stem cells to Pancreatic Beta Cells
Gustavo Tiscornia
Universidade do Algarve (UAlg)

EXCL/BIM-MED/0192/2012

HEARTISSUE: Integrative studies on the role of Ccbe1 in cardiogenesis: from the embryo to Scalable Multipronged Generation of hES-cell derived Myocardial progenitors for heart repair
José António Henriques de Conde Belo
Universidade do Algarve (UAlg)

PTDC/BIM-ONC/0171/2012

Mutant E-Cadherin and Novel Interactors in Cancer (MECANIC). The role of mutant E-cadherin-integrin-ECM crosstalk in gastric cancer.
Raquel Seruca
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/BIM-ONC/0979/2012

A breath to overcome lung cancer: EGFR targeted nanoparticles to carry photodynamic therapy
Maria Filomena Rabaça Roque Botelho
Universidade de Coimbra (UC)

PTDC/BIM-MEC/0282/2012

Molecular mechanisms in the clearance of protein aggregates in misfolding disorders
Maria João Gameiro de Mascarenhas Saraiva
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-MEC/0651/2012

Exploring miRNA contribution to amyloid-b-metabolism: development of a novel lentiviral platform for multiple miRNA expression in Alzheimer´s disease
Ana Luísa Colaço Cardoso
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/BIM-MEC/0913/2012

From neuroinflammation control to neuroprotection: blocking adenosine A2A receptor for the treatment of glaucoma
Ana Raquel Sarabando Santiago
Universidade de Coimbra (UC)

PTDC/BIM-MEC/0998/2012

Left ventricular reverse remodeling after overload relief: potential role of microRNAs as biomarkers and therapeutic targets
Inês Falcão Pires
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/BIM-MET/0739/2012

Understanding the contribution of iron overload in non-alcoholic fatty liver disease: identification of cellular players and potential molecular therapeutic targets
Tiago Pereira de Lacerda Costa Duarte
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/BIM-MED/1047/2012

Y1 receptor based therapy for local bone repair: Antagonist behavior and delivery in challenged bone microenvironment
Meriem Lamghari Moubarrad
Instituto Nacional de Engenharia Biomédica - INEB Univ. Porto (INEB Porto)

PTDC/BIM-MED/1118/2012

Combinatorial approaches to promote cell survival - PROSURVIVAL
Hugo Agostinho Machado Fernandes
Centro de Neurociências e Biologia Celular (CNBC/UC)

EXCL/BIM-MEC/0055/2012

Diastolic heart failure: unraveling novel pathophysiologic mechanisms as potential therapeutic targets
Joaquim Adelino Correia Ferreira Leite Moreira
Faculdade de Medicina da Universidade do Porto (FM/UP)

EXPL/BIM-ONC/0056/2012

Regulation of Bax activation by the oncogene PKCepsilon: An approach to eliminate cancer cells
Rui Filipe Duarte da Silva
Universidade do Minho (UM)

EXPL/BIM-ONC/0556/2012

Discovery of novel microRNA genes epigenetically down-regulated in prostate cancer
Carmen Jerónimo
Instituto Português de Oncologia do Porto Francisco Gentil, EPE (IPO Porto)

EXPL/BIM-MEC/0149/2012

T cell receptor N-glycosylation as a new mechanism underlying Inflammatory Bowel Disease pathogenesis. Implications for therapy.
Salomé Soares de Pinho
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

EXPL/BIM-MEC/0206/2012

Ghrelin implications in ocular angiogenesis. Role in the pathophysiology of diabetic retinopahty.
Amandio Rocha Sousa
Faculdade de Medicina da Universidade do Porto (FM/UP)

EXPL/BIM-MEC/0239/2012

Determinants of neuron-specific pathogenesis: study in a C. elegans model of Machado-Joseph disease
Andreia Cristiana Teixeira de Castro
Universidade do Minho (UM)

EXPL/BIM-MEC/0415/2012

Finding new Pain-genes: whole-exome sequencing of human patients.
OFÉLIA MARIA VIEIRA PINTO DE CARVALHO
Faculdade de Medicina da Universidade do Porto (FM/UP)

EXPL/BIM-MET/0618/2012

Anti-ghrelin vaccine: a feasible alternative for obesity treatment?
LÍDIA MARIANA RODRIGUES PEREIRA MONTEIRO
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

EXPL/BIM-MED/0492/2012

Mechanisms and treatment strategies of impaired wound healing in diabetes
Susana Cecília Brito Gomes Guerreiro
Centro de Neurociências e Biologia Celular (CNBC/UC)