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R&D Projects

Neurosciences, Ageing and Degenerative Diseases Evaluation Panel - 2012

Evaluation

Carlos Fitzsimons
Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Netherlands
Guy Orban
Research Group Neurophysiology, Katholieke Universiteit, Leuven, Belgium
Joe Herbert
Department of Clinical Neurosciences, University of Cambridge, United Kingdom
Leszek Kaczmarek
Nencki Institute, Warsaw, Poland
Marina Bentivoglio
Faculty of Medicine, University of Verona, Italy
Michael George Stewart
The open University - Milton Keynes, United Kingdom
Tibor Harkany
Karolinska Institutet, Stockholm, Sweden

Projects assigned

FCT-ANR/NEU-NMC/0022/2012

Translational and mechanistic approaches on carbon monoxide as a modulator of neuroinflammation and neuroprotection in glial cells
Helena Luisa de Araujo Vieira
Faculdade de Ciências Médicas (FCM/UNL)

FCT-ANR/NEU-NMC/0037/2012

Targeting protein aggregation as a therapeutic approach in polyglutamine expansion disorders
Patrícia Espinheira de Sá Maciel
Instituto de Biologia Molecular e Celular (IBMC/UP)

FCT-ANR/NEU-NMC/0107/2012

Intercellular transmission of α-synuclein and tau in Alzheimer's and Parkinson's diseases
Tiago Outeiro
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

FCT-ANR/NEU-NMC/0120/2012

Dissecting striatal functions of Foxp1 and Foxp2 in social behavior and habit formation
Rui Costa
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

FCT-ANR/NEU-NMC/0134/2012

Targeted Multimodal Imaging Agents for the Detection of Abeta Plaques in Alzheimer's Disease
Carlos Geraldes
Centro de Neurociências e Biologia Celular (CNBC/UC)

FCT-ANR/NEU-NMC/0259/2012

Superresolution imaging of synaptic plasticity
Rosalina Maria Regada Carvalho Fonseca de Alvarez
Fundação Calouste Gulbenkian (FCG)

FCT-ANR/NEU-SCC/0058/2012

Rehabilitation of Balance capacities of hemiparetic patients by a seesaw device
Abel Rouboa
Universidade de Trás-os-Montes e Alto Douro (UTAD)

FCT-ANR/NEU-SCC/0255/2012

Homeostatic Regulation of Energy Metabolism in the Brain
Christian Machens
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

FCT-ANR/NEU-BEN/0009/2012

Instrumental role of A2A receptors in aging and Alzheimer's disease
Luisa Vaqueiro Lopes
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

FCT-ANR/NEU-OSD/0159/2012

Bridging anxiety and addiction: the role of the bed nucleus of the stria terminalis in stress-related mental disorders
JOSÉ MIGUEL GOMES MOREIRA PÊGO
Universidade do Minho (UM)

FCT-ANR/NEU-OSD/0199/2012

Contribution of PAC1 and VPAC1 receptors to functional recovery after stroke.
Diana Lina Jerónimo da Cunha Reis
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

FCT-ANR/NEU-OSD/0202/2012

Modulating ER stress to prevent Parkinson's Disease
Pedro Manuel Dias Neto Domingos
ITQB NOVA - Instituto de Tecnologia Química e Biológica António Xavier (ITQB NOVA/UNL)

FCT-ANR/NEU-OSD/0258/2012

Adaptive and maladaptive response to stress: longitudinal characterization in brain imaging and molecular correlates
Nuno Jorge Carvalho de Sousa
Universidade do Minho (UM)

PTDC/NEU-NMC/0035/2012

The role of neuronal intracellular traffic in Alzheimer´s disease
Cláudia Guimas Almeida
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/NEU-NMC/0036/2012

Non-motor symptoms in PD: exploring novel targets in synucleinopathies
Luisa Vaqueiro Lopes
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-NMC/0047/2012

Alterations of the synaptic proteome in the pilocarpine model of temporal lobe epilepsy: effect of different antiepileptic treatments
Carlos Jorge Alves Miranda Bandeira Duarte
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/0063/2012

Regulation of ubiquitin-proteasome system in brain ischemia: impact on neuronal proteome
Margarida Alexandra Vaz Caldeira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/0088/2012

Modulating Actin Dynamics during axon formation, growth and regeneration: the role of adducin and profilin.
Monica M Sousa
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-NMC/0092/2012

Is CB1 epigenetically regulated? Role of stress and Drd2
Ana João Gomes Rodrigues
Universidade do Minho (UM)

PTDC/NEU-NMC/0105/2012

Autophagy, metabolic shift, hypoxia and carbon monoxide: implications for adult neurogenesis
Helena Luisa de Araujo Vieira
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/NEU-NMC/0119/2012

Transcription regulation and mitochondrial function in Alzheimer's disease - effect of early targeting the NMDA receptor
Ana Cristina Carvalho Rego
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/0123/2012

Testing Transthyretin (TTR) stability as a key factor in TTR/A-Beta interaction in vivo- use of TTR stabilizers and impact in TTR levels, A-Beta peptide transport and uptake
Isabel dos Santos Cardoso
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-NMC/0225/2012

Neuron-glia cross-talk in chronic pain processing: role of ATF3 in primary afferents
Fani Lourença Moreira Neto
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/NEU-NMC/0248/2012

Unraveling the neuroprotective role of TUDCA in Parkinson´s disease: targeting oxidative stress and mitophagy
Margarida Casal Ribeiro Castro Caldas Braga
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/NEU-NMC/0285/2012

Novel strategy against Alzheimer's disease: restoring endogenous BDNF activity
Maria José de Oliveira Diógenes Nogueira
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-NMC/0315/2012

Transcriptional integration of Notch and Proneural pathways in vertebrate neurogenesis
Diogo Pinto da Cruz Sampaio e Castro
Fundação Calouste Gulbenkian (FCG)

PTDC/NEU-NMC/0372/2012

Liraglutide as a novel therapeutic tool against Alzheimer´s disease: a study focused on insulin signaling and mitochondria
PAULA ISABEL DA SILVA MOREIRA
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/0378/2012

Targeting cholesterol homeostasis in Alzheimer´s disease: Neuroprotective mechanisms of tauroursodeoxycholic acid
Joana São José Dias Amaral
Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa)

PTDC/NEU-NMC/0381/2012

Neonatal Hyperbilirubinemia: impact on the developmental program of the brain
Dora Brites
Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa)

PTDC/NEU-NMC/0383/2012

Sirtuin 3, a new therapeutic target in Parkinson's disease
Sandra Morais Cardoso
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/0543/2012

Molecular mechanisms regulating Interleukin-10 expression in microglia activated via Toll-like receptors.
Margarida Saraiva
Universidade do Minho (UM)

PTDC/NEU-NMC/0592/2012

Zebrafish as a model for studying Parkinson´s disease
Ana Dulce de Ascensao Almeida Correia
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-NMC/0632/2012

APP, BRI2 and BRI3 intracellular targeting and RIP signaling as key regulatory mechanisms in neurodegenerative diseases
Sandra Maria Tavares da Costa Rebelo
Universidade de Aveiro (UA)

PTDC/NEU-NMC/0687/2012

Spinal cord injury: understanding and treating the neurogenic bladder
Célia da Conceição Duarte Cruz
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-NMC/0706/2012

TAp63γ and its targets in neurogenesis: therapeutic potential of tauroursodeoxycholic acid
Filipa Nunes
Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa)

PTDC/NEU-NMC/0716/2012

Modeling alpha-synuclein biology in Drosophila melanogaster to target the molecular basis of Parkinson's disease
Pedro Manuel Dias Neto Domingos
ITQB NOVA - Instituto de Tecnologia Química e Biológica António Xavier (ITQB NOVA/UNL)

PTDC/NEU-NMC/0784/2012

Is glycinergic transmission a potential therapeutic target for epilepsy ?
Cláudia Alexandra dos Santos Valente de Castro
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-NMC/0818/2012

Unveiling the genetic and epigenetic regulation of adult neurogenesis in depression and its modulation by antidepressants: new molecular targets for better treatments
Luisa Pinto
Universidade do Minho (UM)

PTDC/NEU-NMC/0990/2012

Sirtuin 2: a link between ageing and neurodegeneration
Tiago Outeiro
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-NMC/1040/2012

Neuronal mechanisms of pheromonal action in the tilapia (Oreochromis mossambicus).
Peter Hubbard
Centro de Ciências do Mar (CCMar)

PTDC/NEU-NMC/1096/2012

GABA & glutamate high affinity transport modulation by purines in epilepsy
Joao Miguel da Silva Cordeiro
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/NEU-NMC/1122/2012

Avaliação do perfil inflamatório de doentes com Degenerescência lobar frontotemporal com mutações no gene da progranulina
Maria do Rosário Pires Maia Neves de Almeida
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/1161/2012

Metabolic modifications in a type 3 diabetic model of sporadic Alzheimer´s disease- control by adenosine A2A receptors
PAULA MARIA GARCIA AGOSTINHO
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/1231/2012

Searching for therapeutic targets of stroke differentially expressed in the cerebrospinal fluid and choroid plexus of male and female rats
Cecília Reis Alves SANTOS
Universidade da Beira Interior (UBI)

PTDC/NEU-NMC/1276/2012

Neural control of locomotor speed in larval zebrafish
Michael Orger
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/NEU-NMC/1303/2012

ARE PURINES ORCHESTRATING MYENTERIC SYNAPSES?
Margarida Duarte Cerqueira Martins de Araújo
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/NEU-NMC/1387/2012

Glycoalkaloids potential for Alzheimer's disease therapeutics
Paula Cristina Branquinho de Andrade
Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares - Porto (ICETA-Porto/ICETA)

PTDC/NEU-NMC/1570/2012

Exploring SMN2 3´ UTR regulators for SMA therapeutics
Margarida Henriques da Gama Carvalho
Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa)

PTDC/NEU-NMC/1616/2012

Physiopathological role of adenosine A2A receptors in astrocytes
PAULA MARIA GARCIA AGOSTINHO
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/1683/2012

Synaptic Dysfunction in Early Epileptic Encephalopathies: From genes to function
Inbal Israely
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/NEU-SCC/0201/2012

Positive Affect, Emotions, and Pain Perception in Fibromyalgia
Gina Maria Costa Caetano
Universidade de Coimbra (UC)

PTDC/NEU-SCC/0354/2012

Novel peripheral biomarkers for early Alzheimer's Disease
Ines Baldeiras
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-SCC/0380/2012

Testing a novel hypothesis in schizophrenia: the cerebrospinal fluid dynamics during development.
Joana de Almeida Santos Pacheco Palha
Universidade do Minho (UM)

PTDC/NEU-SCC/0382/2012

IsCAPE: Impact of Stress in Impulsive, Compulsive, Addictive and Personality/Emotional disorders
Ana João Gomes Rodrigues
Universidade do Minho (UM)

PTDC/NEU-SCC/0420/2012

A multi-center, randomized,controlled, rater-blind, 26-weeks trial to evaluate the efficacy of a speech therapy program in patients with the diagnosis of Primary Progressive Aphasia
Manuela Guerreiro
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-SCC/0524/2012

Neuropsychological Tests for Multiple Sclerosis: Validation of a battery for the Portuguese Population
Maria José Pontes Marques de Sá
ISCTE - Instituto Universitário de Lisboa (ISCTE-IUL)

PTDC/NEU-SCC/0525/2012

Parkinson disease and noradrenergic modulation: physiopathological evaluation of nutritional state in parkinsonian rats with bilateral subthalamic nucleus stimulation
Maria Augusta Vieira Coelho
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-SCC/0610/2012

The role of MCH neurons in the reward value of sucrose
Ana Domingos
Fundação Calouste Gulbenkian (FCG)

PTDC/NEU-SCC/0630/2012

Female sexual behavior: serotonin´s role on arousal termination
Susana Q Lima
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/NEU-SCC/0653/2012

Chemotherapy-induced neuropathy in diabetic animals: impairment of serotoninergic pain modulation from the brain?
Isaura Ferreira Tavares
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/NEU-SCC/0661/2012

Mutation types and possible disease modifiers in chorea-acanthocytosis (ChAc): analysis of the VPS13A, HTT and JPH3 genes in a large ChAc patient cohort
Gabriel Miltenberger-Miltenyi
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-SCC/0696/2012

Behavior and Neurobiology in Reelin Pathway Disease
Isabel Alexandra Azevedo Silveira
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-SCC/0762/2012

The effects of prenatal stress in the endocannabinoid system in relation with the brain-gut axis
Ana Raquel Franky Gomes Carvalho
Universidade do Minho (UM)

PTDC/NEU-SCC/0877/2012

Preventing cognitive decline in Alzheimer's disease (AD), aging and temporal lobe epilepsy (TLE) with cognitive training tasks: insights from combined therapy with anti-epileptic or anti-glycation drugs.
Diana Lina Jerónimo da Cunha Reis
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-SCC/0921/2012

Challenging the "Dual Frequency Filter" model of visual processing: an hierarchical study of visual brain asymmetries
Maria Fatima Loureiro
Universidade de Coimbra (UC)

PTDC/NEU-SCC/0939/2012

Dissecting the role of galanin and its receptors in pain-depression comorbidity
Filipa Santos Costa Pinto-Ribeiro
Universidade do Minho (UM)

PTDC/NEU-SCC/1204/2012

Novel Molecular and Magnetic Resonance imaging approaches to identify pathology in the Papez circuit in Alzheimer´s Disease
João Miguel Santos Pereira
Universidade de Coimbra (UC)

PTDC/NEU-SCC/1237/2012

EEG analysis through stochastic equations: applications to Epilepsy
Pedro Goncalves Lind
Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa)

PTDC/NEU-SCC/1321/2012

Automated analysis of female receptivity in Drosophila
Maria Luisa Caramalho Abrunhosa Vasconcelos
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/NEU-SCC/1415/2012

Oxytocin and social buffering of fear memories
Marta de Aragão Pacheco Moita
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/NEU-SCC/1424/2012

High-sugar diet effects in neuronal survival and oxidative stress in the hippocampus of the young Rat
José Paulo Alves Vieira de Andrade
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/NEU-SCC/1473/2012

Improved Peripheral Vision by NeuroFeebback
Fernando Melicio
Instituto Superior de Engenharia de Lisboa (ISEL/IPL)

PTDC/NEU-SCC/1476/2012

Regulation of feminine sexual behavior: Is it GABA or glutamate?
Susana Isabel Ferreira da Silva de Sá
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/NEU-SCC/1480/2012

TAU protein as a novel molecular sculptor of pain perception and processing: implications to Alzheimer´s disease
Hugo Miguel do Vale Leite Santos de Almeida
Universidade do Minho (UM)

PTDC/NEU-SCC/1546/2012

Structural and functional brain impact of painful and silent neuropathies
Hugo Miguel do Vale Leite Santos de Almeida
Universidade do Minho (UM)

PTDC/NEU-SCC/1574/2012

Cooperation and competition in the amygdala: differential role of thalamic and cortical projections in auditory discrimination
Rosalina Maria Regada Carvalho Fonseca de Alvarez
Fundação Calouste Gulbenkian (FCG)

PTDC/NEU-SCC/1580/2012

ESCAPE - Enhancing the Social Competence of children with Autism sPEctrum disorders
Nuno Lobo Antunes
CADIn - Centro de Apoio ao Desenvolvimento Infantil (CADIn)

PTDC/NEU-SCC/1677/2012

Neurovascular and neurometabolic uncoupling in brain aging and neurodegeneration: a vascular nitric oxide-driven redox stress hypothesis
João António Nave Laranjinha
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-SCC/1716/2012

The role of time in associative learning
Marta de Aragão Pacheco Moita
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/NEU-BEN/0053/2012

Validation of an animal model and diagnostic tools applied to vulnerable atherosclerotic plaque
Maria Isabel Machado Prata
Universidade de Coimbra (UC)

PTDC/NEU-BEN/0227/2012

Prediction of dementia at 5 years. A clinical cohort study in non-demented patients with cognitive complaints
Alexandre Valério de Mendonça
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-BEN/0396/2012

Role of sirtuins in epigenetic regulation of age-dependent endothelium dysfunction.
Delminda Gamelas Neves Lopes de Magalhaes
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/NEU-BEN/0441/2012

Molecular characterization of longevity genes in Daphnia: a new model in Aging REsearch
Raquel M Silva
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/NEU-BEN/0585/2012

The interplay between proteostasis and sphingolipid signalling in cellular ageing and disease
Vítor Manuel Vieira da Costa
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-BEN/0609/2012

Erythropoietic disturbances associated with aging: focus on kidney and inflammation
Elisio Manuel Sousa Costa
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-BEN/0648/2012

Can the aged brain benefit from ghrelin signalling?
Rosa Maria Branco de Matos Costa Resende
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-BEN/0665/2012

Exploring the barriers of the brain to understand aging and Alzheimer's disease
Joana de Almeida Santos Pacheco Palha
Universidade do Minho (UM)

PTDC/NEU-BEN/1129/2012

Microglial-neuronal signaling in Alzheimer's disease: sorting out the good from the evil
Rui Fernando Marques da Silva
Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa)

PTDC/NEU-BEN/1166/2012

Can hEROs fight against Alzheimer's disease?
Cláudia Maria Fragão Pereira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-BEN/1192/2012

Age-related hearing loss: Genetic risk factors and social impact
Maria Helena Caria
Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa)

PTDC/NEU-BEN/1382/2012

Deciphering the non-coding transcriptome of human cell aging
Francisco Javier Enguita
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-BEN/1684/2012

Preservation of sensory and motor capacities in life-extended Drosophila
Agavni Petrosyan
Universidade do Minho (UM)

PTDC/NEU-OSD/0034/2012

Interplay between psychostimulant drugs and alpha-synuclein. Role in neurologic impairment.
MARIA TERESA MARTINS DA CUNHA OLIVEIRA
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-OSD/0245/2012

Role of megalin ligands in brain injury
Maria João Gameiro de Mascarenhas Saraiva
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-OSD/0249/2012

Amyotrophic Lateral Sclerosis (ALS): gene silencing and immunotherapy in the transgenic mice model carrying the human SOD1G93A mutation
Paula Alexandra Costa Marçal Correia
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-OSD/0310/2012

Molecular mechanisms underlying brain dysfunction after menopause in type 2 diabetes-associated obesity: the impact of exendin-4 therapy
Ana Isabel Marques Duarte
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-OSD/0361/2012

Looking for a drug for ischemic stroke treatment
Fernanda Maria Fernandes Roleira
Universidade de Coimbra (UC)

PTDC/NEU-OSD/0473/2012

Enhancement of endogenous neurogenesis by nitric oxide: identification of S-nitrosylation targets
Inês Maria Pombinho de Araújo
Universidade do Algarve (UAlg)

PTDC/NEU-OSD/0502/2012

S-Glutathionylation in Parkinson´s Disease.
Maria João Carlos da Silva Gama
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/NEU-OSD/0889/2012

Neuroinflammation and aberrant neurogenesis in the epileptogenic framework: two double-edge swords cooperating in the pathophysiology of epilepsy
Joao Jose Oliveira Malva
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-OSD/0903/2012

A3 adenosine receptor activation for the treatment of glaucoma using a novel sustained-release intravitreal drug delivery system
Ana Raquel Sarabando Santiago
Universidade de Coimbra (UC)

PTDC/NEU-OSD/1238/2012

Adenosine, there is more to diabetic retinopathy than meets the eye
Paulo Fernando Martins dos Santos
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-OSD/1285/2012

S100B/RAGE axis: a promising source of biomarkers and pharmacological tools in PD
Frederico Guilherme de Sousa da Costa Pereira
Universidade de Coimbra (UC)

PTDC/NEU-OSD/1301/2012

From Parkinson's disease to dopamine dysregulation syndrome: the balance of dopamine in the brain
António José Braga Osório Gomes Salgado
Universidade do Minho (UM)

PTDC/NEU-OSD/1367/2012

PREDICTORS OF RISK FOR INCAPACITY ON SENIOR POPULATION FROM LOURES COMMUNITY
Beatriz Fernandes
Instituto Politécnico de Lisboa (IPL)

PTDC/NEU-OSD/1391/2012

Synthesis and Biological Evaluation of New Pyrindane Derivatives as Potential anti-Parkinson and/or anti-Alzheimer Agents
José Enrique Rodríguez Borges
Faculdade de Ciências da Universidade do Porto (FCUP/UP)

EXPL/NEU-NMC/0009/2012

Hemopressin as a modulator of oligodendrogenesis: relevance for a mouse model of multiple sclerosis
Sara Xapelli
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

EXPL/NEU-NMC/0020/2012

Epigenetic regulation of hippocampal function: impact on early life stress
Joana Esteves Coelho
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

EXPL/NEU-NMC/0028/2012

Modulation of the bidirectional communication between neurons and astrocytes by BDNF and P2 receptors at the synapse: relevance to the modulation of synaptic and network activity
Sandra Cristina Henriques Vaz
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

EXPL/NEU-NMC/0114/2012

The role of histone deacetylases in mutant huntingtin acetylation and degradation: relevance for autophagy and neuroprotection in Hutington's Disease.
Tatiana Rosado Rosenstock
Centro de Neurociências e Biologia Celular (CNBC/UC)

EXPL/NEU-NMC/0130/2012

Design, synthesis and bioevaluation of novel blood-brain barrier permeant peptidomimetic BACE-1 inhibitors
Helder João Ferreira Vila Real
Instituto de Biologia Experimental e Tecnológica (IBET)

EXPL/NEU-NMC/0131/2012

Searching for the microRNA maestro in the central regulation of food intake and obesity
Ligia Maria de Sousa Ferreira
Centro de Neurociências e Biologia Celular (CNBC/UC)

EXPL/NEU-NMC/0185/2012

Restoring cellular cross-talk in Amyotrophic Lateral Sclerosis by targeting microglia
Ana Rita Mendonça Vaz Botelho
Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa)

EXPL/NEU-NMC/0210/2012

RhoA contribution to neurodegeneration and neurorepair in brain ischemia
Sofia Santos
Instituto de Biologia Molecular e Celular (IBMC/UP)

EXPL/NEU-NMC/0229/2012

Study of synaptic dysfunction in a mouse model of Machado-Joseph disease
Anabela Silva Fernandes
Instituto de Biologia Molecular e Celular (IBMC/UP)

EXPL/NEU-NMC/0342/2012

Can modulation of RhoGTPase signaling impact on long-term methamphetamine-induced neuronal morphological and functional changes in the brain?
Maria Teresa Burnay Summavielle
Instituto de Biologia Molecular e Celular (IBMC/UP)

EXPL/NEU-NMC/0385/2012

Cross-talk between synapses and microglia as a key bolster of neurodegeneration - control by adenosine A2A receptors
Catarina Alexandra Reis Vale Gomes
Centro de Neurociências e Biologia Celular (CNBC/UC)

EXPL/NEU-NMC/0447/2012

ROLE OF PINCH PROTEINS IN THE MYELINATION OF THE OPTIC NERVE
Joana Paes de Faria
Instituto de Biologia Molecular e Celular (IBMC/UP)

EXPL/NEU-NMC/0497/2012

Olfactory Adaptation for Treating Epilepsy
Fábio Marques Simões de Souza
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

EXPL/NEU-NMC/0594/2012

Diabetic wound healing mechanisms - The role of corticotropin-releasing hormone
João Moura Alves
Centro de Neurociências e Biologia Celular (CNBC/UC)

EXPL/NEU-NMC/0607/2012

Parkinson´s disease: Ferritin Heavy chain confers protection against brain iron accumulation
Raffaella Gozzelino
Fundação Calouste Gulbenkian (FCG)

EXPL/NEU-NMC/0694/2012

proNGF-induced neuronal degeneration: a genetic screen
Ramiro Almeida
Centro de Neurociências e Biologia Celular (CNBC/UC)

EXPL/NEU-SCC/0186/2012

Anti-apolipoprotein A-I antibodies in the pathogenesis of Alzheimer disease
Ana Maria Herrero Valverde
Faculdade de Ciências Médicas (FCM/UNL)

EXPL/NEU-SCC/0223/2012

Understanding altruistic motivations: development of a new animal model
Cristina Márquez
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

EXPL/NEU-SCC/0227/2012

Behind the origin of Alzheimer´s disease: acute inflammatory injury as a trigger for memory and adult neurogenesis decline
Jorge Valero Gómez-Lobo
Centro de Neurociências e Biologia Celular (CNBC/UC)

EXPL/NEU-SCC/0554/2012

Analysis of ultrasonic vocalizations on adult rats
José António Almeida Costa da Cruz
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

EXPL/NEU-SCC/0557/2012

Microfabrication of novel devices for recording neural activity
Adam Raymond Kampff
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

EXPL/NEU-SCC/0665/2012

Developing bulk calcium imaging technique in the hypothalamus
Kensaku Nomoto
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

EXPL/NEU-BEN/0042/2012

Is the differential cognitive decline related with the immunesenescence profile among aged individuals?
SUSANA CRISTINA ROQUE DE OLIVEIRA
Universidade do Minho (UM)

EXPL/NEU-BEN/0078/2012

Defining the role of NMDA receptors on hippocampal neurogenesis in a transgenic mice model of Alzheimer's disease under hyperglycemia
Elisabete Ferreiro
Centro de Neurociências e Biologia Celular (CNBC/UC)

EXPL/NEU-BEN/0233/2012

GluN2A and -B subunits composition and activation defects of N-Methyl-D-Aspartate Receptors in Alzheimer's disease
Ildete Luísa de Araújo Ferreira
Centro de Neurociências e Biologia Celular (CNBC/UC)

EXPL/NEU-BEN/0446/2012

Caloric restriction as an anti-aging strategy by preventing the blood-brain barrier(s) dysfunction: eat less, keep the brain young and live longer
Célia Alexandra Ferreira de Oliveira Aveleira
Centro de Neurociências e Biologia Celular (CNBC/UC)

EXPL/NEU-OSD/0345/2012

Similarities between the failure to integrate the path in homing pigeons and Alzheimer disease patients. The role of olfactory input.
Paulo Alexandre Esteves Jorge
ISPA,CRL (ISPA)

EXPL/NEU-OSD/0606/2012

Alpha-synuclein as a blood biomarker for Parkinson's disease
Hugo Miguel Vicente Miranda
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

RECI/NEU-NMC/0222/2012

Synapse formation and function in health and disease
João Peça
Centro de Neurociências e Biologia Celular (CNBC/UC)

RECI/NEU-SCC/0066/2012

A multimodal electrophysiology cluster to bridge neuroscience studies from animal models to humans
João Filipe Oliveira
Universidade do Minho (UM)

RECI/NEU-SCC/0105/2012

Linking molecular and functional anatomy of the healthy ageing and degenerating brain: a multimodal approach
Miguel de Sá e Sousa de Castelo Branco
Universidade de Coimbra (UC)

RECI/NEU-BEN/0216/2012

Getting old fast: the advantage of intermediate animal models to study age-related diseases
Catarina Oliveira
Universidade de Coimbra (UC)

EXCL/NEU-NMC/0087/2012

Physiopathological role of adenosine A2A receptors - caffeinated clues for brain diseases
Rodrigo Antunes Cunha
Centro de Neurociências e Biologia Celular (CNBC/UC)

EXCL/NEU-SCC/0019/2012

Combating chronic visceral pain
Francisco José Miranda Rodrigues Cruz
Instituto de Biologia Molecular e Celular (IBMC/UP)

EXCL/NEU-SCC/0054/2012

Integrative approach to the Stressed Brain: an open window for neuroplasticity
Nuno Jorge Carvalho de Sousa
Universidade do Minho (UM)

EXCL/NEU-BEN/0048/2012

Endocannabinoid CB1 receptor regulation at hippocampal synapes: implications for memory function across ageing
Ana Maria Ferreira Sousa Sebastião
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-NMC/0198/2012

Downregulation of the GABAergic synaptic transmission in brain ischemia - molecular mechanisms of GABAA receptor internalization
Carlos Jorge Alves Miranda Bandeira Duarte
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/0205/2012

DJ-1 neuronal rescue under oxidative stress: implications for Parkinson's disease
BRUNO JOSÉ FERNANDES OLIVEIRA MANADAS
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/0237/2012

KDAC inhibition and intracellular dynamics: impact on NEUROnal development, survival and transmission
Jorge Miguel de Ascenção Oliveira
Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares - Porto (ICETA-Porto/ICETA)

PTDC/NEU-NMC/0494/2012

Monosynaptic convergence of somatic and visceral nociceptive afferents onto spinal lamina I neurons as mechanism of referred pain
Boris Safronov
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-NMC/0750/2012

A Novel Model for Schizophrenia: Defects in Stargazin-Mediated Homeostatic Plasticity.
Ana Luisa Carvalho
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/1098/2012

Effects of the orexigenic peptide ghrelin on glutamatergic synaptic transmission
Sandra Manuela Domingues dos Santos
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-SCC/0347/2012

Bisynaptic inhibition of spinal nociceptive projection neurons by low-threshold Aβ-afferents: a new gate in control of pain
Boris Safronov
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-SCC/0767/2012

Movement Disorders in Autistic Spectrum Disorders
Teresa Maria Pereira Padrão Temudo
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/NEU-SCC/1351/2012

Tackling Alzheimer's Disease with a new peptide inhibitor of BACE1
Armanda Emanuela Castro e Santos
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-SCC/1516/2012

Modulation of fronto-hippocampal circuit oscillations: neurophysiological and behavioral correlates
Vasco Miguel Clara Lopes Galhardo
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/NEU-BEN/0125/2012

Proteostasis as a link between longevity pathways and neurodegenerative diseases
Patrícia Espinheira de Sá Maciel
Universidade do Minho (UM)

PTDC/NEU-BEN/0156/2012

Modulation of microglial reactivity by GDNF: relevance to dopaminergic protection
Graça Maria Fernandes Baltazar
Universidade da Beira Interior (UBI)

PTDC/NEU-OSD/0312/2012

Methylphenidate and blood-brain barrier changes in health and attention deficit hyperactivity disorder
Ana Paula Pereira da Silva Martins
Universidade de Coimbra (UC)

PTDC/NEU-OSD/1113/2012

Neuropeptide Y system: a new potential therapeutic target in diabetic retinopathy.
António Francisco Rosa Gomes Ambrósio
Universidade de Coimbra (UC)

RECI/NEU-NMC/0138/2012

Molecular mechanisms of chronic pain: an integrated approach based on genetically manipulated animal models
Deolinda Maria Valente Alves Lima Teixeira
Faculdade de Medicina da Universidade do Porto (FM/UP)

EXPL/NEU-NMC/0331/2012

Silencing Machado-Joseph Disease through the systemic route
Rui Jorge Nobre
Centro de Neurociências e Biologia Celular (CNBC/UC)

EXPL/NEU-NMC/0380/2012

Identification of new players of Rho 1 signalling pathway involved in delivering Rho1 message in the nucleus
Ligia Maria Silva Tavares
Instituto de Biologia Molecular e Celular (IBMC/UP)

EXPL/NEU-NMC/0541/2012

Mechanism underlying ribosomal regulation in axonal development
Rui Miguel Oliveira da Costa
Centro de Neurociências e Biologia Celular (CNBC/UC)

EXPL/NEU-NMC/0671/2012

Role of P2Y1 receptors on neuronal polarity and axonal growth: implications for mossy fiber sprouting in epileptic phenomena.
Ricardo Jorge Alves Rodrigues
Centro de Neurociências e Biologia Celular (CNBC/UC)