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R&D Projects

Proposals for Research Projects in all Scientific Domains - 2006

Painel de Avaliação de Orgãos e Sistemas, Metabolismo, Nutrição e Toxicologia - 2006

Coordination

Alice Warley
CUI King's College London, United Kingdom

Evaluation

Adrian Bomford
Institute of Liver Studies, United Kingdom
Alice Warley
David Chambers
The Rayne Institute, United Kingdom
Per-Anders Jansson
The Sahlgrenska Academy at Gteburg University, Sweden

Projects assigned

PTDC/SAU-OSM/64323/2006

Inhibition by Doxorubicin of H9c2 Cell Apoptosis Caused by Isoproterenol-induced Stimulation of Beta-Adrenergic Receptors - Mitochondrial-Dependent and Independent Mechanisms
Paulo Jorge Gouveia Simoes Da Silva Oliveira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/SAU-OSM/64381/2006

Profiling of multiple hemoglobin covalent modifications as a means for diagnosing metabolic diseases
Armindo José Alves da Silva Salvador
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/SAU-OSM/64413/2006

INNATE IMMUNITY RECEPTOR INHIBITION IN AN ANIMAL MODEL OF DIET-INDUCED OBESITY. IMPLICATIONS FOR THE METABOLIC SYNDROME.
Roberto Liberal Fernandes Roncon de Albuquerque
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/SAU-OSM/64454/2006

Biomonitoring and Genetic Susceptibility of individuals exposed to Arsenic- BIOGENEAs
João Paulo Fernandes Teixeira
Instituto Nacional de Saúde Dr. Ricardo Jorge (INSARJ)

PTDC/SAU-OSM/64536/2006

Development of Novel Techniques for Surgery by Natural Orifices
Jorge Manuel Nunes Correia Pinto
Universidade do Minho (UM)

PTDC/SAU-OSM/64612/2006

The role of glucocorticoids and immunosuppressive agents in the impairment of glucose and lipid metabolism observed in the metabolic syndrome
EUGÉNIA MARIA LOURENÇO DE CARVALHO
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/SAU-OSM/64617/2006

Hyperglycaemia-induced Mitochondrial Dysfunction on Differentiated H9c2 Myoblasts: Role of Mitochondrial Permeability Transition and Relevance for Diabetic Cardiomyopathy
Paulo Jorge Gouveia Simoes Da Silva Oliveira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/SAU-OSM/64724/2006

Cross-talk between immune system and iron metabolism: the role of ceruloplasmin synthesized by human peripheral blood lymphocytes.
LUCIANA MARIA GONÇALVES DA COSTA
Instituto Nacional de Saúde Dr. Ricardo Jorge (INSARJ)

PTDC/SAU-OSM/64763/2006

Vitamin A effects on lung vasculogenesis and angiogenesis during foetal and perinatal development
Vasco Antonio Andrade Figueiredo Bairos
Universidade de Coimbra (UC)

PTDC/SAU-OSM/65358/2006

Limonoids and polymethoxylated flavones in citrus: isolation, bioactivity and bioavailability
Maria do Rosário Beja de Figueiredo Gonzaga Bronze
Instituto de Biologia Experimental e Tecnológica (IBET)

PTDC/SAU-OSM/65463/2006

The role of the adipocyte as an endocrine organ in congestive heart failure - the impact of insulin resistance
EUGÉNIA MARIA LOURENÇO DE CARVALHO
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/SAU-OSM/65467/2006

The gut in secondary injury after experimental brain trauma. New therapeutical approaches.
José Alejandro Ribeiro dos Santos
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/SAU-OSM/65468/2006

Molecular study of atherosclerosis and endothelial inflammation effects in vascular remodelling and vasculogenic erectile dysfunction progression.
Delminda Gamelas Neves Lopes de Magalhaes
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/SAU-OSM/65868/2006

AQUATOX - Identification and monitoring of environmental pollutants affecting bone metabolism
Vincent Laizé
Centro de Ciências do Mar (CCMar)

PTDC/SAU-OSM/65873/2006

AMYOTROPHIC LATERAL SCLEROSIS: fatigue, exercise and neuroprotection studies
Mamede de Carvalho
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/SAU-OSM/65951/2006

Granule biogenesis in the exocrine pancreas: Identification and molecular characterization of granule membrane proteins in health and disease
Michael Schrader
Universidade de Aveiro (UA)

PTDC/SAU-OSM/66102/2006

Food intake, hyperhomocysteinaemia and cardiovascular disease in type 2 diabetes: A population-based case-control study
Maria Helena Rodrigues Gonçalves Soares Costa
Instituto Nacional de Saúde Dr. Ricardo Jorge (INSARJ)

PTDC/SAU-OSM/66323/2006

Nutraceuticals: a shield against chronic disease? -contribution for the rationale of a new therapeutic option-
António José Murinello de Sousa Guerreiro
Pró-INSA, Associação para a Promoção da Investigação em Saúde (Pró-INSA/INSARJ)

PTDC/SAU-OSM/66334/2006

Novel PP1 binding proteins and their potential role in the control of sperm motility
Edgar Figueiredo da Cruz e Silva
Universidade de Aveiro (UA)

PTDC/SAU-OSM/66463/2006

Biological aspects underlying the clinical outcome of Hereditary Spherocytosis
Alice Santos-Silva
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/SAU-OSM/66770/2006

Biologically Active Amines in Taditional Portuguese Foods: Intake, Biovailability and Adverse Effects
Olivia Maria Castro Pinho
Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares - Porto (ICETA-Porto/ICETA)

PTDC/SAU-OSM/66797/2006

Study of functionality of cyclic nucleotides compartmentalization in vascular smooth muscle cells
Ignacio Verde
Universidade da Beira Interior (UBI)

PTDC/SAU-OSM/67145/2006

Toxicoproteomics: protein biomarkers for the control and prevention of methylmercury toxicity
Cristina Maria Leitão de Carvalho
Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa)

PTDC/SAU-OSM/67214/2006

Toxicokinetic and toxicological consequences of the interactions between ethanol and pharmaceutical drugs used in association with 3,4-methylenedioxymethamphetamine (MDMA, ecstasy). Evaluating the risks of polydrug intake
Maria de Lourdes Bastos
Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares - Porto (ICETA-Porto/ICETA)

PTDC/SAU-OSM/67426/2006

Soluble prodrugs of biologically active flavones and flavanones (SOPROFLAV)
Ana Luisa Ferreira Simplicio
Instituto de Biologia Experimental e Tecnológica (IBET)

PTDC/SAU-OSM/67457/2006

Role of the vagus nerve and brainstem pathways in the mechanisms of gastro-intestinal hormones induced weight loss
Maria Helena Cardoso Pereira da Silva
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/SAU-OSM/67499/2006

Obesity, hypertension and autonomic nervous system: biomarkers of endothelial dysfunction and inflammatory cytokines
Maria Irene de Oliveira Monteiro Jesus Rebelo
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/SAU-OSM/67526/2006

Molecular diagnosis of congenital adrenal hyperplasia due to 11-hydroxylase deficiency
lurdes lopes
Hospital de Dona Estefânia (HDE/CHLC)

PTDC/SAU-OSM/67552/2006

Obesity and cardiovascular risk: from genetics to environmental influences
José António Silva-Nunes
Escola Superior de Tecnologia da Saúde de Lisboa (ESTeSL/IPL)

PTDC/SAU-OSM/67553/2006

Influence of fat mass reduction on cardiovascular risk associated with obesity
José António Silva-Nunes
Escola Superior de Tecnologia da Saúde de Lisboa (ESTeSL/IPL)

PTDC/SAU-OSM/67663/2006

Genotoxic and carcinogenic potencial of microcystins. Contribution to risk assessment of human exposure to freshwater cyanobacteria
Maria João Aleixo da Silva
Pró-INSA, Associação para a Promoção da Investigação em Saúde (Pró-INSA/INSARJ)

PTDC/SAU-OSM/67866/2006

Chromosome instability in Fanconi Anemia (FA): looking for prevention, from genomics to phenomics
Maria Beatriz Beça Gonçalves Porto e Vasconcelos
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/SAU-OSM/67867/2006

Pathology induced by industrial infrasound
MARIA JOÃO FEYTOR PINTO RODRIGUES DE OLIVEIRA DE MEIRELES MOREIRA
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/SAU-OSM/68300/2006

CD1d expression and distribution under anomalies of sphingolipid metabolism: implications for Gaucher and Fabry disease
Fernando Aguilar Arosa
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/SAU-OSM/68825/2006

The future of fatty livers in surgery and transplantation: is preconditioning and mitochondrial tolerance a useful strategy to overcome ischemia/reperfusion injury?
Anabela Pinto Rolo
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/SAU-OSM/69630/2006

Nutrigenomics: Folic acid in cancer development
Miguel Brito
Escola Superior de Tecnologia da Saúde de Lisboa (ESTeSL/IPL)

PTDC/SAU-OSM/69920/2006

Study of novel genes expressed in the H/HPC for a correct control of heart organogenesis.
José António Henriques de Conde Belo
Universidade do Algarve (UAlg)

PTDC/SAU-OSM/70284/2006

ONCOLACT - Application of new tools to study the mechanisms underlying health benefits of lactoferrin.
LIGIA RAQUEL MARONA RODRIGUES
Universidade do Minho (UM)

PTDC/SAU-OSM/70560/2006

Rationale and options in dietary use of canned sardines in olive oil and tomato (omega 3, lycopene, and oleic acid) related to inflammatory and aterotrombogenic biomarkers in obesity and metabolic syndrome related cardiovascular disease
Pedro Orlando Rodrigues
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/SAU-OSM/70591/2006

Diabetes: osteoporosis and cardiovascular calcification
Maria João dos Reis Conceição Martins Almeida Ribeiro
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/SAU-OSM/70849/2006

The influence of calcium ion activity on the behaviour of extra cellular physiological fluids
Albertina Maria Mendes Marques Bento Amaro
Universidade da Beira Interior (UBI)

PTDC/SAU-OSM/70950/2006

Study of the migration of potentially migrant chemicals from plastic packaging into foodstuffs. Use of mathematical modelling for easier food safety assessment.
Ana Sanches Silva
Instituto Nacional de Saúde Dr. Ricardo Jorge (INSARJ)

PTDC/SAU-OSM/70965/2006

High intensity training as a risk factor for for hepatic steatosis/steatohepatitis. Correlation between hepatic and muscle fat
Helena Cortez-Pinto
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/SAU-OSM/70966/2006

cAMP/PKA pathway regulates insulin sensitivity by affecting hepatic GSH levels.
Maria Paula Borges de Lemos Macedo
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/SAU-OSM/71169/2006

Characterization of the evolution of macular edema and associated vision loss
MARIA DA CONCEIÇÃO LOPES LOBO DA FONSECA
Associação para a Investigação Biomédica e Inovação em Luz e Imagem (AIBILI)

PTDC/SAU-OSM/71229/2006

Early inflammatory events in diabetic retinopathy: molecular mechanisms underlying interleukin-1 beta-induced blood-retinal barrier breakdown
António Francisco Rosa Gomes Ambrósio
Faculdade de Medicina da Universidade de Coimbra (FM/UC)

PTDC/SAU-OSM/71385/2006

Nutritional regulation of intestinal glucose transporters in diabetes control.
Cristina Maria Da Silveira e Silva Pereira Wilson
Universidade do Minho (UM)

PTDC/SAU-OSM/71443/2006

WHITE-COAT HYPERTENSION. BLOOD PRESSURE REACTIVITY TO STRESSFUL HEMODYAMIC AND PSYCHOLOGICAL STIMULI.
Jorge Manuel Silva Junqueira Polonia
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/SAU-OSM/71504/2006

Nutritional approches to colon cancer prevention
Cristina Maria Da Silveira e Silva Pereira Wilson
Universidade do Minho (UM)

PTDC/SAU-OSM/71507/2006

BioNat - Natural Bioproducts, an alternative approach in Cancer Chemoprevention, Chemotherapy and Chronic Inflammation
Catarina Maria Martins Duarte
Instituto de Biologia Experimental e Tecnológica (IBET)

PTDC/SAU-OSM/71613/2006

Teeth elemental profiles measured by X-ray fluorescence: dietary habits and environmental influence
José Manuel Pires Marques
Fundação da Universidade de Lisboa (FUL/ULisboa)

PTDC/SAU-OSM/72390/2006

Impact of metabolic syndrome, its componets and proposed therapies on the heart, blood vessels, kidney and liver
LINO MANUEL MARTINS GONÇALVES
Faculdade de Medicina da Universidade de Coimbra (FM/UC)

PTDC/SAU-OSM/72635/2006

Validation of a predictive model to estimate the risk of conversion to clinically significant macular edema and/or vision loss in mild nonproliferative diabetic retinopathy in diabetes type 2.
José Cunha-Vaz
Associação para a Investigação Biomédica e Inovação em Luz e Imagem (AIBILI)

PTDC/SAU-OSM/72882/2006

Assessment of guanylin peptides system in diabetes, with or without renal insufficiency.
Benedita Sampaio Maia
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/SAU-OSM/73003/2006

Predictive value of blood-retinal barrier alterations for progression of vision loss in eyes with Age-related Macular Degeneration and Geographic Atrophy. A 2-years prospective study.
Rufino Martins da Silva
Associação para a Investigação Biomédica e Inovação em Luz e Imagem (AIBILI)

PTDC/SAU-OSM/73449/2006

FIBRINOGEN-DEPENDENT SIGNALLING IN MICROVASCULAR BLOOD CELL FUNCTION - IMPLICATIONS OF INFLAMMATION AND CARDIOVASCULAR DISEASE.
Maria Carlota Saldanha Lopes
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/SAU-OSM/73906/2006

Expression, function and regulation of G protein-coupled receptor kinases (GRKs) in inflammatory bowel disease
Sónia Fraga
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/SAU-OSM/74095/2006

Adipocyte-derived hormones and induction of atherogenesis
Luisa Maria Carvalho Veiga
Escola Superior de Tecnologia da Saúde de Lisboa (ESTeSL/IPL)

PTDC/SAU-OSM/74376/2006

MODULATION OF CARDIOVASCULAR ADAPTATION TO DISEASE: IMPACT OF STEM CELL TRANSPLANTATION ON POST MYOCARDIAL INFARCT REMODELLING AND ARRHYTHMIAS
Luis Afonso Bras Simoes Rosario
Fundação Calouste Gulbenkian (FCG)

PTDC/SAU-OSM/74766/2006

Determinants of left ventricular hypertrophy before and after surgical treatment of aortic stenosis: clinical, morphofunctional, genetic and molecular correlations
Joaquim Adelino Correia Ferreira Leite Moreira
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/SAU-OSM/75814/2006

Oxidative stress and atherogenesis: role of acrolein and hydrogen peroxide in the development of vascular lesions
António Albino-Teixeira
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/SAU-OSM/78608/2006

Effects of adipocyte-derived hormones on oxidative stress in metabolic syndrome associated to coronary disease
Luisa Maria Carvalho Veiga
Escola Superior de Tecnologia da Saúde de Lisboa (ESTeSL/IPL)

PTDC/SAU-OSM/80586/2006

Pesticide exposure in greenhouses. Genotoxicity and genetic susceptibility. “AgriGen”
OLGA NILZA BILBAO DE SOUSA MAYAN GONÇALVES
Instituto Nacional de Saúde Dr. Ricardo Jorge (INSARJ)

PTDC/SAU-OSM/81378/2006

Interactions between the hypothalamus-pituitary-adrenal and hypothalamus-pituitary-gonadal axes of the rat during chronic ´binge´ cocaine and withdrawal
Pedro Monteiro
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/SAU-OSM/64084/2006

Novel Mitochondrial Mechanisms of Doxorubicin-induced Selective Cardiotoxicity
Paulo Jorge Gouveia Simoes Da Silva Oliveira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/SAU-OSM/64093/2006

Growth factors in health and disease
Maria João Gameiro de Mascarenhas Saraiva
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/SAU-OSM/64643/2006

Diabetes and the somatosensory system: effects of dysfunctions in insulin and its related peptides in painful diabetic neuropathy
Isaura Ferreira Tavares
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/SAU-OSM/65140/2006

Disruption of hepatic glucose and lipid metabolism by immunosuppressive agents: implications for diagnosis and treatment of posttransplant diabetes
John Griffith Jones
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/SAU-OSM/65599/2006

Bone marrow derived cell therapy for diabetes-associated erectile dysfunction
Carla Sofia Rodrigues da Costa
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/SAU-OSM/67498/2006

A new route for endothelial dysfunction on diabetes: From phenotypes to molecules
Henrique Girao
Associação para a Investigação Biomédica e Inovação em Luz e Imagem (AIBILI)

PTDC/SAU-OSM/67936/2006

Metabolic activity and viability of chondrocytes in cryopreserved human osteochondral allografts
Maria Celeste Fernandes Lopes
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/SAU-OSM/68204/2006

Changes in gastro-intestinal hormones after weight loss induced by bariatric surgery with gastric banding
Maria Helena Cardoso Pereira da Silva
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/SAU-OSM/68473/2006

Towards the establishment of cell-based therapy for repairing cardiac-injury: characterization, purification and functional analysis of potential therapeutic-beneficial cell-subsets.
Perpetua Pinto do Ó
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/SAU-OSM/72443/2006

Disturbance of the physiologic pathways and molecular mechanisms regulating energy homeostasis in obesity and metabolic syndrome: searching new strategies and therapeutic targets
Carlos Palmeira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/SAU-OSM/73576/2006

ORIGIN AND FATE OF EXTRACELLULAR PURINES REGULATING HUMAN BONE FORMATION
Paulo Correia de Sá
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)