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R&D Projects

Proposals for Research Projects in all Scientific Domains - 2006

Painel de Avaliação de Oncobiologia e Biologia do Desenvolvimento - 2006

Coordination

Carlos Caldas
Department of Oncology, University of Cambridge, Functional Breast Cancer Genomics Laboratory, Cancer Research UK Cambridge Research Institute, United Kingdom

Evaluation

Carlos Caldas
Gabriel Capella
Laboratori de Recerca Translacional, Institut Català d'Oncologia, Spain
K. Becker
Klinikum rechts der Isar der Technischen Universitaet, Institut fuer Pathologie, Germany
Miguel Constancia
Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, United Kingdom
Nick Lemoine
Institute of Cancer & CR-UK Clinical Centre, Barts & The London School of Medicine, United Kingdom
Paul Pharoah
Cancer Research UK Senior Clinical Research Fellow, Dept. of Oncology, University of Cambridge, United Kingdom

Projects assigned

PTDC/SAU-OBD/64014/2006

The T- antigen as a prognostic marker of superficial bladder cancer treated with BCG
Paula Alexandra Quintela Videira
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/SAU-OBD/64157/2006

Caracterização dos mecanismos moleculares de biosíntese das estruturas de carbohidratos determinantes dos antigénios Sialyl-Lewis em células epiteliais gástricas.
Celso Albuquerque Reis
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/SAU-OBD/64165/2006

Notch-signaling in Embryonic Hematopoiesis. A view from the microenvironment.
Maria Leonor Sa Barreiros Silva Parreira
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/SAU-OBD/64628/2006

Functional study of the molecular clock during vertebrate limb development
Maria Leonor Tavares Saúde
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/SAU-OBD/64912/2006

Characterization of the cellular and molecular mechanisms responsible for the formation of a polarized epithelium in Drosophila melanogaster.
Rui Gonçalo Viegas Russo da Conceição Martinho
Fundação Calouste Gulbenkian (FCG)

PTDC/SAU-OBD/65057/2006

Whole human genome analysis of genetic imbalances and numerical abnormalities in gliomas: correlation with clinical and biological features of the disease
Maria Celeste Fernandes Lopes
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/SAU-OBD/65238/2006

A New Metabolic Method For Diagnosis and Prognosis of Drug-sensitive and Drug-resistant Tumours
Maria Carmen Alpoim
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/SAU-OBD/65349/2006

Interplay between transcriptional regulation and morphogenesis in the vertebrate embryo
Ana Teresa Fernandes Nunes Tavares
Fundação Calouste Gulbenkian (FCG)

PTDC/SAU-OBD/65547/2006

Molecular Features Underlying “Basal-Like” Breast Carcinomas
Fernando Schmitt
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/SAU-OBD/65747/2006

Is host-susceptibility/resistance to Helicobacter pylori infection mediated by DMBT1 gene expression variability?
Ana Rita Estrela Rodrigues Conde
Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa)

PTDC/SAU-OBD/65766/2006

NEW THERAPEUTICAL STRATEGIES AGAINST BREAST CANCER: Pharmacological and toxicological characterization of new drugs
José Barata Antunes Custódio
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/SAU-OBD/65771/2006

Overexpression of Rac1b in tumours without oncogenic Ras mutations: an alternative genetic pathway in colorectal tumour progression?
Paulo Henrique Carrasquinho de Matos
Pró-INSA, Associação para a Promoção da Investigação em Saúde (Pró-INSA/INSARJ)

PTDC/SAU-OBD/65844/2006

The role of ion dynamics during vertebrate limb development and regeneration
Ana Catarina Certal
Fundação Calouste Gulbenkian (FCG)

PTDC/SAU-OBD/65982/2006

Role of RAS (signalling/splicing mechanisms) in the aneuploidization of tumour cells.
Ana Paula Soares Dias Ferreira
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/SAU-OBD/66040/2006

Bacterial redox proteins as anticancer agents: strategies for the validation and improvement of their anticancer efficacy using Drosophila melanogaster as a model
Arsénio Carmo Sales Mendes Fialho
Instituto Superior Técnico (IST/ULisboa)

PTDC/SAU-OBD/66264/2006

Tubulin Cofactor A: searching for new roles in testis development
Maria Helena Antunes Soares
Fundação Calouste Gulbenkian (FCG)

PTDC/SAU-OBD/66438/2006

Inhibiton of genomic instability by telomere protection
Miguel Godinho Ferreira
Fundação Calouste Gulbenkian (FCG)

PTDC/SAU-OBD/66579/2006

Characterization of chicken PRICKLE protein interactions during embryonic development
Isabel Maria Corrêa Calvente de Barahona
Egas Moniz - Cooperativa de Ensino Superior, CRL (CESEM)

PTDC/SAU-OBD/66615/2006

Identification of Epigenetic Markers for Molecular Detection of Urological Cancers using Genome-wide RNA Expression Profiling
Carmen Jerónimo
Instituto Português de Oncologia de Francisco Gentil, Centro Regional de Oncologia do Porto (IPO Porto)

PTDC/SAU-OBD/67694/2006

Metastases, invasion and dedifferentiation of thyroid carcinomas: molecular characterization and search for new therapeutic targets
Valeriano Alberto Pais Horta Leite
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/SAU-OBD/67755/2006

ClearCRCancer - STUDY OF NEW PROGNOSTIC FACTORS OF COLORECTAL CANCER.
José Guilherme Lopes Rodrigues Tralhão
Faculdade de Medicina da Universidade de Coimbra (FM/UC)

PTDC/SAU-OBD/67829/2006

Functional role of GRIM-19 mutations in thyroid tumours: Emphasis in Hürthle cell tumours
Valdemar de Jesus Conde Máximo
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/SAU-OBD/68592/2006

INsect cell vectorS as biofactoriEs for the produCtion of recombinanT PROteins for innovative cancer therapies
Maria do Carmo Pinto Basto Avides Moreira
Universidade do Minho (UM)

PTDC/SAU-OBD/69578/2006

Mutator pathway impact on genesis and progression of aberrant crypt foci
PEDRO MANUEL NARRA DE FIGUEIREDO
Faculdade de Medicina da Universidade de Coimbra (FM/UC)

PTDC/SAU-OBD/69636/2006

Cancer patients' Quality of Life measurement in daily practice
Francisco Luis Maia Mamede Pimentel
Universidade de Aveiro (UA)

PTDC/SAU-OBD/69928/2006

Genetic and biochemical control of Cerl-2 activity during early development
José António Henriques de Conde Belo
Universidade do Algarve (UAlg)

PTDC/SAU-OBD/69974/2006

Molecular and Functional Effects of TAL1 and LMO2 Overexpression in Normal Human Hematopoietic Stem Cells: Impact on T-cell leukemogenesis.
João Pedro Taborda Barata
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/SAU-OBD/70141/2006

Study of molecular therapeutic target c-Kit in brain tumours
RUI MANUEL VIEIRA REIS
Universidade do Minho (UM)

PTDC/SAU-OBD/70269/2006

Reactive Oxygen species in cumullus oophorus cells, modulating oocyte quality
Henrique Almeida
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/SAU-OBD/70611/2006

CHROMOSOMAL AND GENE EXPRESSION ALTERATIONS ASSOCIATED WITH INVASIVE GROWTH PATTERNS AND PROGNOSIS OF GLIOMAS
Maria Lúcia Primo Nobre de Oliveira Roque
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/SAU-OBD/70782/2006

Vasculature activation and tumor re-growth after radiotherapy
Susana Constantino Rosa Santos
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/SAU-OBD/71023/2006

Clinicopathological influence of aberrant promoter hypermethylation of tumor supressor and DNA repair genes in non-small cell lung cancer
Lina Maria Rodrigues Carvalho
Faculdade de Medicina da Universidade de Coimbra (FM/UC)

PTDC/SAU-OBD/71172/2006

Cell proliferation, survival and tumor angiogenesis: the role of genetic markers on viral associated neoplasias
RUI Manuel de MEDEIROS Melo Silva MEDEIROS
Instituto Português de Oncologia de Francisco Gentil, Centro Regional de Oncologia do Porto (IPO Porto)

PTDC/SAU-OBD/71173/2006

Estudo da variabilidade genetica de factores de risco associados ao cancro da mama hormonodependente
Luiza Augusta Tereza Gil Breitenfeld Granadeiro
Universidade da Beira Interior (UBI)

PTDC/SAU-OBD/71305/2006

Endometrial malignancy: study of the involvement of the human chromosomal region 10q26 and molecular characterization of radiotherapy resistance
Carolino Jose Nunes Monteiro
Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa)

PTDC/SAU-OBD/71387/2006

NANOsiRNA - polymeric biodegradable nanoparticles for siRNA transport in oncology therapeutics
Rogério Paulo Pinto de Sá Gaspar
Faculdade de Farmácia da Universidade de Lisboa (FF/ULisboa)

PTDC/SAU-OBD/71596/2006

Identification of the direct target genes of Terra using a ChIP-on-chip approach
Maria Leonor Tavares Saúde
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/SAU-OBD/71937/2006

Molecular defects in Myelodysplastic Syndromes and Secondary Acute Myeloblastic Leukemia - A multicentric study to improve a rationally based signalling therapeutic strategies
Ana Bela Sarmento Ribeiro
Faculdade de Medicina da Universidade de Coimbra (FM/UC)

PTDC/SAU-OBD/72088/2006

Photochemotoxicity: optimizing the therapeutical use by elimination of undesired effects
Amilcar Elizeu Rato da Silva Roberto
COFAC, Cooperativa de Formação e Animação Cultural, CRL (COFAC)

PTDC/SAU-OBD/72302/2006

Importance of transbronchial needle aspiration guided by endobronchial ultrasound in lung cancer staging.
Maria João Costa Santos Mattos Marques Gomes
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/SAU-OBD/72993/2006

Individualized prediction of resistance of breast tumors to primary chemotherapy using an ex vivo chemoresistance assay and proteomic tumor profiling
Euclides Pires
BIOCANT - Associação de Transferência de Tecnologia (BIOCANT)

PTDC/SAU-OBD/73112/2006

Molecular mechanisms of bone formation during caudal fin regeneration in zebrafish
António Alfredo Coelho Jacinto
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/SAU-OBD/73113/2006

Identification and characterization of novel endothelial genes involved in regenerating blood vessels in zebrafish and their application to develop anti-angiogenic drug targets for cancer therapy
António Alfredo Coelho Jacinto
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/SAU-OBD/73148/2006

Assessement of the in vitro and in vivo oncogenic potential of genes regulated by the oncogenic TEL-JAK2 fusion protein in T-cell leukaemia
Nuno Alexandre Pinto Rodrigues dos Santos
Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE (IPO Lisboa)

PTDC/SAU-OBD/73160/2006

Understanding cellular senescence in the context of cancer chemotherapy - the role of chromatin biogenesis
João António Augusto Ferreira
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/SAU-OBD/73191/2006

Using Drosophila to understand the molecular control of actin dynamics in aberrant active cell migration
Florence Janody
Fundação Calouste Gulbenkian (FCG)

PTDC/SAU-OBD/73194/2006

Regulation Of The Function Of The Tumourigenesis-Associated Kinase SAK/PLK4
Monica Bettencourt Carvalho Dias
Fundação Calouste Gulbenkian (FCG)

PTDC/SAU-OBD/73228/2006

Molecular analysis of endosonography-guided aspirates in the diagnosis of pancreatic carcinoma
JOSE MANUEL VILHENA OLIVEIRA SILVA PONTES
Faculdade de Medicina da Universidade de Coimbra (FM/UC)

PTDC/SAU-OBD/73600/2006

Metastases in squamous-cell carcinoma of the Head and Neck: identification of related genomic and proteomic factors
Lúcio Lara Santos
Instituto Português de Oncologia de Francisco Gentil, Centro Regional de Oncologia do Porto (IPO Porto)

PTDC/SAU-OBD/73944/2006

Molecular mechanisms underlying the involvement of hepsin in prostate cancer
Carlos José Fialho Costa Faro
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/SAU-OBD/74350/2006

Molecular analysis of pancreatic cyst fluid in predicting the potential of malignancy
JOSE MANUEL VILHENA OLIVEIRA SILVA PONTES
Faculdade de Medicina da Universidade de Coimbra (FM/UC)

PTDC/SAU-OBD/75068/2006

Genetic control of self renewal vs differentiation decisions in myogenic progenitors
Jennifer Rowland
Fundação Calouste Gulbenkian (FCG)

PTDC/SAU-OBD/75106/2006

Notch signaling and regulatory mechanisms during mammalian neurogenesis
Domingos Manuel Pinto Henrique
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/SAU-OBD/75514/2006

Molecular analysis of RET/PTC´s function in papillary thyroid cancer (PTC) by targeted genetic manipulation of a human PTC cell line
Manuel Sobrinho Simoes
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/SAU-OBD/81223/2006

Clinical, genetic and molecular study of the agenesis of maxillary lateral incisors
Elsa Logarinho
Cooperativa de Ensino Superior Politécnico e Universitário, CRL (CESPU)

PTDC/SAU-OBD/64319/2006

Exploring the role of E-cadherin trafficking deregulation in epithelial cancer progression.
Gianpaolo Suriano
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/SAU-OBD/64490/2006

CDX2 autoregulation in the reversibility/irreversibility of gastric intestinal metaplasia
Raquel Maria da Silva Graça Almeida
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/SAU-OBD/65616/2006

IDENTIFICATION OF SIGNALING PATHWAYS MEDIATED BY MUC1 ONCOGENE IN GASTRIC CARCINOMA CELL LINES AND IMMORTALIZED GASTRIC CELLS
Luis Filipe Santos Silva
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/SAU-OBD/66113/2006

Functional Dissection of Mammalian CLASPs and their Interacting Proteins - Implications for Aneuploidy and Cancer
Helder Jose Martins Maiato
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/SAU-OBD/68310/2006

MLK3, a new mutated gene in MSI colorectal cancer
Raquel Seruca
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/SAU-OBD/69787/2006

Molecular and functional characterization of the mTOR pathway in papillary thyroid carcinoma
Ana Sofia Semião Correia da Rocha
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/SAU-OBD/70543/2006

Characterization of fusion genes involving the ETS family of transcription factors and their role as diagnostic and prognostic markers in prostate cancer
Manuel António Rodrigues Teixeira
Instituto Português de Oncologia do Porto Francisco Gentil, EPE (IPO Porto)