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R&D Projects

Scientific Research and Technological Development Projects - 2014

Neurosciences, Ageing and Degenerative Diseases Evaluation Panel - 2014

Coordination

Leszek Kaczmarek
Nencki Institute, Poland

Evaluation

Albert Compte
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, Spain
André Mouraux
Université Catholique de Louvain, Belgium
Giandomenico Iannetti
Department of Neuroscience, Physiology and Pharmacology, University College London, United Kingdom
James Douglas Armstrong
University of Edinburgh, School of Informatics, United Kingdom
Marco Racchi
University of Pavia - Dept of Drug Sciences - Pharmacology Unit, Italy
Michael George Stewart
The Open University, United Kingdom
Tarja Stenberg
Institute of Biomedicine/Physiology, Faculty of Medicine, University of Helsinki, Finland
Tibor Harkany
Karolinska Institutet, Sweden
Veerle Baekelandt
Research Group for Neurobiology and Gene Therapy, Department of Neurosciences, KU Leuven, Belgium

Projects assigned

PTDC/NEU-NMC/0068/2014

Understanding how regulators of endosomal trafficking and actin cytoskeleton bin1 and cd2ap increase the risk of developing Alzheimer´s disease
Cláudia Guimas Almeida
Faculdade de Ciências Médicas (FCM/UNL)

P2020-PTDC/NEU-NMC/0084/2014

Gene repair and repression strategies to alleviate Machado-Joseph disease
LUÍS FERNANDO MORGADO PEREIRA DE ALMEIDA
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/0157/2014

Neurotoxic astrocytes as potential therapeutic targets in amyotrophic lateral sclerosis: modulating microvesicles/exosomes and their microRNA cargo
Dora Brites
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/NEU-NMC/0246/2014

Role of alternative SNAP isoforms SNAP-29 and SNAP-47 in exocitosis and neurotransmitter release
Paulo César Silva Pinheiro
Centro de Neurociências e Biologia Celular (CNBC/UC)

P2020-PTDC/NEU-NMC/0412/2014

Targeting huntingtin proteostasis and mitochondria to prevent neuronal dysfunction in Huntington’s disease
Jorge Miguel de Ascenção Oliveira
ICETA - Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA)

PTDC/NEU-NMC/0434/2014

Characterization of the vulnerable atherosclerotic plaque: a preclinical molecular imaging approach

Maria Isabel Machado Prata
Universidade de Coimbra (UC)

PTDC/NEU-NMC/0456/2014

The transcriptional program of the proneural factor Ascl1 and its function in Glioblastoma cancer stem cells
Diogo Pinto da Cruz Sampaio e Castro
Fundação Calouste Gulbenkian (FCG)

PTDC/NEU-NMC/0552/2014

Calpain-mediated proteolysis in Machado-Joseph disease: biomarker and therapeutic target
Ana Teresa Antunes Simões
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/0654/2014

BDNF, astrocytes and gliotransmitters: working together to shape synaptic plasticity?
Sandra Cristina Henriques Vaz
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-NMC/0828/2014

Unravelling the mechanisms of alpha-synuclein and ataxin-3 spreading in Parkinson and Machado Joseph diseases. On the intersection of exosome secretion and autophagy clearance.
Rita Catarina Gonçalves Perfeito
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/0867/2014

A bacteriophage-based platform for diagnosis and therapeutics of early Alzheimer´s disease
Ivone Marisa Pereira Martins
Universidade do Minho (UM)

PTDC/NEU-NMC/0998/2014

A neurobiological substrate for the actions of ghrelin on cognition
Sandra Manuela Domingues dos Santos
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/1135/2014

Molecular and Cellular Characterization of SAPAP3, involved in Obsessive Compulsive Disorder.
Pedro Miguel Dias Castanheira
BIOCANT - Associação de Transferência de Tecnologia (BIOCANT)

PTDC/NEU-NMC/1213/2014

Modulação da transcrição de alvos oxidativos na doença de Alzheimer ­ papel da classe I das desacetilases de histonas
Elisabete Ferreiro
Centro de Neurociências e Biologia Celular (CNBC/UC)

P2020-PTDC/NEU-NMC/1259/2014

Pre- and postsynaptic interactions between afferents supplying lamina I projection neurons in the lumbar and cervical spinal cord: impact for somatic pain and migraine
Boris Safronov
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-NMC/1311/2014

Mind the GAP
Odete A B da Cruz e Silva
Universidade de Aveiro (UA)

PTDC/NEU-NMC/1332/2014

P2Y1 Receptor controls synaptic and memory loss in early Alzheimer´s disease
Joana Medeiros Vieira Marques
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/1474/2014

Adducin and Actin rings in Axon biology: from polarity and transport, to degeneration and myelination.
Monica M Sousa
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-NMC/1496/2014

Effects of caloric restriction in the clearance of amyloid-beta by choroid plexus epithelial cells: a sex-related approach.
Helena Marcelino
Universidade da Beira Interior (UBI)

PTDC/NEU-NMC/1577/2014

Mitochondrial quality control, cell metabolism and carbon monoxide: new strategies against cerebral ischemia
Helena Luisa de Araujo Vieira
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/NEU-NMC/1582/2014

Modifiers of Machado-Joseph disease: the role of all MJD class proteases
Sandra Martins
Instituto de Patologia e Imunologia Molecular (IPATIMUP/UP)

PTDC/NEU-NMC/1755/2014

Amphetamines and neuronal morphology: cytoskeleton regulation in drug abuse
Andrea Catarina Amaro de Campos Lobo
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-NMC/1964/2014

Using a lethal neurotoxin to fight pain
António Avelino Ferreira Saraiva da Silva
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/NEU-NMC/2138/2014

The calcium binding S100B protein as a modulator of amyloid β aggregation and a potential therapeutic target in Alzheimer’s disease
Cláudio Emanuel Moreira Gomes
FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências (Fciências.ID)

PTDC/NEU-NMC/2168/2014

Probing the mechanisms of epileptogenesis for potential therapeutic targets
Cláudia Alexandra dos Santos Valente de Castro
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-NMC/2193/2014

Complex effects of opioids on excitability of spinal nociceptive lamina I neurons
Liliana Luz
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-NMC/2394/2014

Towards an SMA cure: Modulation of SMN2 mRNA expression with target protectors and RNA aptamers for therapeutic intervention
Christian Gomes da Silva Ramos
Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa)

PTDC/NEU-NMC/2420/2014

Role of tumor supressor WWOX1 in type 2 diabetes-associated neurodegeneration
Cristina Carvalho
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/2459/2014

Functional characterization of genes required for neurodegeneration caused by endoplasmic reticulum stress
Pedro Manuel Dias Neto Domingos
ITQB NOVA - Instituto de Tecnologia Química e Biológica António Xavier (ITQB NOVA/UNL)

PTDC/NEU-NMC/2479/2014

Systems Analysis of Inflammation and Neuronal Demise In Parkinson’s Disease
Joana São José Dias Amaral
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/NEU-NMC/2697/2014

Alterations in the synaptic proteome in the pilocarpine model of temporal lobel epilepsy: inter- and intracellular signaling mechanisms
Carlos Jorge Alves Miranda Bandeira Duarte
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/2724/2014

Homeostatic regulation of central nervous system myelin by RhoGTPase Cdc42 signaling
Joao Carlos Bettencourt de Medeiros relvas
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-NMC/3156/2014

Mechanism of aluminium neurotoxic action on (Na+/K+)ATPase activity: Caveolae involvement.
Virgília Sofia Almeida de Azevedo e Silva
Universidade de Aveiro (UA)

PTDC/NEU-NMC/3283/2014

Autophagy and neurogenesis interplay in the hypothalamus: a new target to delay aging?
Ana Rita Álvaro
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/3309/2014

NADPH oxidase 1: a therapeutic target for Parkinson’s disease.
Ana Clara Braz Cristóvão
Universidade da Beira Interior (UBI)

PTDC/NEU-NMC/3316/2014

On-site proteolysis during presynaptic differentiation
Ramiro Almeida
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/3567/2014

Hybrid ionotropic receptors: a new concept of receptor
Ricardo Jorge Alves Rodrigues
Centro de Neurociências e Biologia Celular (CNBC/UC)

P2020-PTDC/NEU-NMC/3648/2014

Role of glial cells in the neurodegenerative process in Machado-Joseph disease
Patrícia Espinheira de Sá Maciel
Universidade do Minho (UM)

PTDC/NEU-NMC/3651/2014

Calbum@PD - Isolation of the protective polyphenols from C. album: a mechanistic study in cellular and animal models of Parkinson’s disease.
Maria Cláudia Nunes dos Santos
Instituto de Biologia Experimental e Tecnológica (IBET)

PTDC/NEU-NMC/3810/2014

Neuronal intracellular trafficking for growth and plasticity
Rita Teodoro
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/NEU-NMC/3811/2014

Histone Deacetylases in Brain Cholesterol Metabolism
Maria Joao de Jesus Nunes
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/NEU-NMC/3885/2014

Cork polyphenols as modulators of ataxin-3 neurotoxicity in Machado-Joseph disease
Ricardo Alexandre Rodrigues Pires
Universidade do Minho (UM)

PTDC/NEU-NMC/4066/2014

Role of SAPAP3 in Huntington’s disease striatal dysfunction
Ana Cristina Carvalho Rego
Centro de Neurociências e Biologia Celular (CNBC/UC)

P2020-PTDC/NEU-NMC/4154/2014

Role of astrocytes in the control of memory-focus on adenosine A2A receptors
PAULA MARIA GARCIA AGOSTINHO
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/4548/2014

Lipid signalling determinants of seizure resistance in Alzheimer’s disease
Tiago Gil Oliveira
Universidade do Minho (UM)

PTDC/NEU-NMC/4605/2014

Neural bases of oriented locomotion in the fly
Maria Eugenia Chiappe
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/NEU-NMC/4742/2014

SCHIZOPHRENIA AS A DISRUPTION OF HOMEOSTATIC PLASTICITY: INSIGHT FROM HUMAN MUTATIONS IN THE CACNG2 GENE
Ana Luisa Carvalho
Centro de Neurociências e Biologia Celular (CNBC/UC)

P2020-PTDC/NEU-NMC/4888/2014

A role for Contactin-associated proteins 1 and 2 in experience-dependent plasticity
Susana Ribeiro dos Louros
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/5167/2014

Inhibition of Abeta-DNA and Abeta-tau interactions as new targets for the treatment of Alzheimer’s disease
Sergio Camero Gigante
Universidade do Minho (UM)

PTDC/NEU-NMC/5209/2014

Sodium vitamin C co-transporter-2 (SVCT2) regulates the pro-inflammatory signature of microglial cells: implications for neurodegeneration
Camila Cabral Portugal
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-NMC/5224/2014

Deciphering the role of HIF-1alpha in Alzheimer’s disease - towards a novel biomarker and therapeutic target
Sónia Catarina de Sousa Correia
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/5446/2014

Prion-like behavior and synergistic interactions in amyotrophic lateral sclerosis
Sónia Cristina Alves Dickson Leal Solano
Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa)

PTDC/NEU-NMC/5568/2014

Determining the basal ganglia circuits involved in repetitive behaviors in Autism Spectrum Disorders
Rui Costa
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/NEU-NMC/5633/2014

Dissecting central-peripheral polarity in dorsal root ganglia neurons
Fernando José Milhazes Mar
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-NMC/5735/2014

Exosomes as biomarkers and gene delivery vectors for Machado-Joseph disease
Rui Jorge Nobre
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/5998/2014

Insulin resistance in hippocampal serotonergic fibers: a handshake between metabolic and mood disorders
Attila Köfalvi
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-NMC/6199/2014

MitoLipidome approaches: Strategies to understand and control the pathophysiology of Alzheimer disease
Romeu António Videira
Universidade de Trás-os-Montes e Alto Douro (UTAD)

PTDC/NEU-NMC/6814/2014

Homeostatic regulation of synaptic connectivity in mouse models of neurodevelopmental disorders
Inbal Israely
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/NEU-NMC/6841/2014

Tackling Tau and IFNg in Down Syndrome and Alzheimer disease pathologies: the path from altered immune system to cognitive decline
Ioannis Sotiropoulos
Universidade do Minho (UM)

PTDC/NEU-SCC/0089/2014

Deciphering the role of nucleus accumbens D1 and D2 neurons in social behavior(s)
Ana João Gomes Rodrigues
Universidade do Minho (UM)

PTDC/NEU-SCC/0111/2014

Mind The Gap: decoding and bridging somatosensory information in the spinal cord
Paulo de Castro Aguiar
Instituto Nacional de Engenharia Biomédica - INEB Univ. Porto (INEB Porto)

PTDC/NEU-SCC/0221/2014

Understanding the Initial Phases of Genetic Frontotemporal Lobar Degeneration - Setting the Stage for Prevention Trials
Alexandre Valério de Mendonça
Associação para Investigação e Desenvolvimento da Faculdade de Medicina (AIDFM/FM/ULisboa)

PTDC/NEU-SCC/0239/2014

Characterization of olfactory avoidance processing in the central brain
Maria Luisa Caramalho Abrunhosa Vasconcelos
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/NEU-SCC/0309/2014

SHEDDING LIGHT ON PAIN-RELATED WORKING-MEMORY DEFICITS: an integrated approach to prefrontal cortex modulation using optogenetics stimulation
Helder Rui Cardoso da Cruz
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/NEU-SCC/0435/2014

FACEIEZ – Functional Approach for Comprehensive Emotional Intelligence in Schizophrenia
Célia Maria de Oliveira Barreto Coimbra Carvalho
Fundação Gaspar Frutuoso, FP (FGF)

PTDC/NEU-SCC/0681/2014

Aging cognitively in-shape: the crossroads of the immune system at the brain barriers
Joana de Almeida Santos Pacheco Palha
Universidade do Minho (UM)

PTDC/NEU-SCC/0801/2014

Longitudinal assessment of neuroophthalmological changes in people with multiple sclerosis
Antonio Filipe Teixeira Macedo
Universidade do Minho (UM)

PTDC/NEU-SCC/0818/2014

Neural Bases of Perception, Memory and Decision
ARMANDO MIGUEL CASEIRO PIRES REMONDES
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-SCC/0948/2014

Decision-making in animal groups: a multidisciplinary approach to understand how social information is processed
GONZALO GARCIA DE POLAVIEJA
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/NEU-SCC/1410/2014

Clarificação do papel do hipocampo ventral na tomada de decisão em condições de ansiedade
Luis Ricardo Monteiro Jacinto
Universidade do Minho (UM)

PTDC/NEU-SCC/1495/2014

Psychostimulants and neuroinflammation: critical players in the crosstalk between microglia, astrocytes and neurons
Maria Teresa Burnay Summavielle
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-SCC/1766/2014

Amylin, an endogenous modulator of chronic pain: focusing on the primary afferent neurons and spinal cord
Catarina Alexandra Soares Potes
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/NEU-SCC/1790/2014

Reticulo-septo-hippocampal circuits in epilepsy
NIKOLAY VSEVOLODOVICH LUKOYANOV
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-SCC/2076/2014

Neuroinflamação no cérebro diabético: um papel na dor crónica e distúrbios de humor.
Carla Sofia da Costa Morgado
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/NEU-SCC/2102/2014

Oxytocin and Dopamine Interaction in Mental Illness - on the Biology of Social Cognition in Psychosis
Diana Maria Pinto Prata
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-SCC/2181/2014

Preventing fall related injuries in Individuals with Parkinson’s disease: development of innovative adapted clothing as a protective fall solution
Joaquim José Coutinho Ferreira
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-SCC/2209/2014

Os microRNAs como importantes reguladores das vias de sinalização do recetor Toll-like 4 na dor articular
Fani Lourença Moreira Neto
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/NEU-SCC/2239/2014

End of Life Care: contribution to training of health professionals at a hospital in Beira Interior Sul
Ana Paula Gonçalves Antunes Sapeta
Instituto Politécnico de Castelo Branco (IPCB)

PTDC/NEU-SCC/2333/2014

Neural encoding of reward in dopaminergic circuits: optogenetic study of the origin and update of neural signals of expectation during decision-making under uncertainty
Vasco Miguel Clara Lopes Galhardo
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/NEU-SCC/2642/2014

Mind-Matter Interaction with Therapeutic Intention through Inside/Out Stimulation‏‏
MÁRIO PINTO SIMÕES
Associação para Investigação e Desenvolvimento da Faculdade de Medicina (AIDFM/FM/ULisboa)

PTDC/NEU-SCC/2713/2014

A genetic model for neurorehabilitation
César S Mendes
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/NEU-SCC/2980/2014

Reducing neurological damage in cardiac surgery with multimodal evaluation
Elsa Azevedo
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/NEU-SCC/3023/2014

Rules of memory allocation: role of actin dynamics in synaptic cooperation and competition
Rosalina Maria Regada Carvalho Fonseca de Alvarez
Faculdade de Ciências Médicas (FCM/UNL)

P2020-PTDC/NEU-SCC/3247/2014

Social hierarchy and early life adversity: optogenetic modulation of prefrontal cortical circuits and neuroepigenetic regulation
João Peça
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-SCC/3336/2014

Consequences of long-term tamoxifen administration to cycling rats on cognitive functions and bone remodeling
Susana Isabel Ferreira da Silva de Sá
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/NEU-SCC/3591/2014

Learning from astrocytes how to treat Depression
Luisa Pinto
Universidade do Minho (UM)

PTDC/NEU-SCC/3685/2014

Rescue of neurological phenotypes due to MEF2C happloinsufficiency in autosomal dominant mental retardation syndrome-20 (MRD20)
Inês Maria Pombinho de Araújo
Universidade do Algarve (UAlg)

PTDC/NEU-SCC/4109/2014

From habit to compulsion: Dissecting the neural circuit basis of behavioral compulsions in mice and men.
Albino Jorge Carvalho de Sousa Oliveira Maia
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/NEU-SCC/4331/2014

Optical dissection of the function of cortical feedback in primary visual cortex.
Leopoldo Petreanu
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/NEU-SCC/4347/2014

Dissecting neuronal circuits and dynamics controlling nutrient homeostasis and stem cell proliferation
Carlos Ribeiro
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/NEU-SCC/4534/2014

Intelligent System for Active, Assisted and Affective Aging
Ana Maria Dias Madureira Pereira
Instituto Superior de Engenharia do Porto (ISEP/IPP)

PTDC/NEU-SCC/4766/2014

High-fat high-sugar diet effects on the hippocampus of young Rat: potential benefits of olive oil and honey antioxidant compounds
Armando Cardoso
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/NEU-SCC/4786/2014

Female socio-sexual behavior: role of hypothalamic neuronal activity across the reproductive cycle
Susana Q Lima
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/NEU-SCC/4817/2014

Neuroprotective effects of novel mitochondria-targeted antioxidants in SOD1 models of familial Amyotrophic Lateral Sclerosis
Fernando Cagide Fagin
Faculdade de Ciências da Universidade do Porto (FCUP/UP)

PTDC/NEU-SCC/4883/2014

Exercise and Cerebral Vasoreactivity: Cognitive modulation in Alzheimer’s Dementia
Maria Carolina Lobo de Almeida Garrett
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/NEU-SCC/4893/2014

Assessing the benefits of multi-sensory and cognitive stimulation in the quality of life of elderly people
Henrique José Rocha ONeill
ISCTE - Instituto Universitário de Lisboa (ISCTE-IUL)

PTDC/NEU-SCC/5156/2014

When antidepressants do not work: can an inflamed gut be the answer?
SUSANA CRISTINA ROQUE DE OLIVEIRA
Universidade do Minho (UM)

PTDC/NEU-SCC/5221/2014

The neural circuit basis of oculomotor behavior in zebrafish
Michael Orger
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/NEU-SCC/5291/2014

The stressed entorhinal cortex: morphological characterization and functional outcome.
Vítor Manuel da Silva Pinto
Universidade do Minho (UM)

P2020-PTDC/NEU-SCC/5301/2014

Where pain and pleasure collide – mesolimbic dopaminergic mediation of chronic pain emergence and associated motivational disorders
Hugo Miguel do Vale Leite Santos de Almeida
Universidade do Minho (UM)

PTDC/NEU-SCC/5617/2014

Apolipoprotein A-I: translational immuno-inflammatory pathways for neurodegenerative diseases
Ana Maria Herrero Valverde
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/NEU-SCC/6050/2014

Cognitive decline in rodent models of cardiovascular disease associated with sympathoexcitation: are they useful to predict the risk to develop dementia and Alzheimer disease?
Diana Lina Jerónimo da Cunha Reis
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-SCC/6628/2014

Use of nanoparticles for improving blood-brain-barrier permeability of curcumin/retinoic acid and their neurogenic effect for the treatment of neurodegenerative and neuropsychiatric disorders
Paulo Jorge Cardoso da Costa
Faculdade de Farmácia da Universidade do Porto (FF/UP)

P2020-PTDC/NEU-SCC/7051/2014

Schizophrenia diagnosis and prognosis: finding the way to a personalized medicine
António Ferreira de Macedo
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-SCC/7140/2014

Old and novel targets to tackle Alzheimer’s disease: the effect of BACE1 and necroptotic inhibitors
Armanda Emanuela Castro e Santos
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-BEN/0834/2014

Interaction between choroid plexus, circadian rhythm and Alzheimer´s disease - the role of Aβ scavengers
Telma Quintela
Universidade da Beira Interior (UBI)

PTDC/NEU-BEN/1091/2014

Age-related bladder symptoms: looking for causes and treatments
Francisco José Miranda Rodrigues Cruz
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-BEN/1738/2014

BDNF receptor fragments produced by Amyloid Beta peptide: their role and usefulness as Alzheimer´s Disease biomarkers.
Maria José de Oliveira Diógenes Nogueira
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-BEN/1746/2014

Alpha-synuclein in synaptic plasticity: the basis of early neuronal dysfunction in Parkinson’s disease
Luisa Vaqueiro Lopes
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/NEU-BEN/1916/2014

Role of tau acetylation in Alzheimer´s disease: towards novel biomarkers and therapeutic targets
Ana Esteves
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-BEN/2010/2014

Role of the epicardial adipose tissue on congestive heart failure and its association with aging
Patricia Monteiro Seraphim
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-BEN/2066/2014

SAge – A multidisciplinary approach to investigate skeletal ageing
Eugenia Maria Guedes Pinto Antunes Cunha
Universidade de Coimbra (UC)

PTDC/NEU-BEN/2278/2014

The interplay between proteostasis and sphingolipid signalling in cellular ageing and disease
Vítor Manuel Vieira da Costa
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-BEN/2685/2014

Peripheral and central interferon levels in Alzheimer´s disease: a translational approach to improve cognitive outcomes
Fernanda Cristina Gomes de Sousa Marques
Universidade do Minho (UM)

PTDC/NEU-BEN/3300/2014

Targeting the hypothalamus to block aging associated with depression
Magda Matos Santana
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-BEN/3368/2014

GPER: A new tool to protect dopaminergic neurons?
Graça Maria Fernandes Baltazar
Universidade da Beira Interior (UBI)

PTDC/NEU-BEN/3798/2014

Diagnosis and clinical decision in ageing sarcopenia: an algorithm proposal to support decision making
Jaime Branco
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/NEU-BEN/4498/2014

REinstatement of hypothalamic neuropeptide Y (NPY) to delay aging and increase LIFEspan
CLÁUDIA MARGARIDA GONÇALVES CAVADAS
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-BEN/4879/2014

Voluntary white wine intake and the brain reward system: influence of wine composition and animal age
Pedro Alberto da Graça Pereira
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/NEU-BEN/4969/2014

Presynaptic dysfunction as a trigger for AD progression
Rui Miguel Oliveira da Costa
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-BEN/5697/2014

The safety of the elderly in residential structures: Fall risk management
Maria dos Anjos Coelho Rodrigues Dixe
Instituto Politécnico de Leiria (IPLeiria)

PTDC/NEU-BEN/6059/2014

Decrypting glycolipid code for Alzheimer’s disease. Are GM1 and ER stress good clues?
Rosa Maria Branco de Matos Costa Resende
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-BEN/6185/2014

Aging-related retrotransposon derepression: insights into neurodegenerative diseases and new prophylactic strategies
Fabiana Herédia
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/NEU-BEN/6463/2014

Evaluation of genetic ancestry effects on Epigenetic estimation of age
Luís Manuel Souto de Miranda
Universidade de Aveiro (UA)

PTDC/NEU-BEN/6888/2014

Modified neurogenesis and cognitive function in diabetic-like Alzheimer´s disease - therapeutical potential of beta-catenin
Catarina Oliveira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-BEN/7156/2014

Telomeres and mTOR: two conflicting pathways regulating organismal senescence
Maria Inês Araújo Pimenta de Castro
Fundação Calouste Gulbenkian (FCG)

PTDC/NEU-OSD/0232/2014

The impact of lixisenatide therapy on brain dysfunction upon co-morbid type 2 diabetes and hypertension
Ana Isabel Marques Duarte
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-OSD/0774/2014

Neuroprotective role of Transthyretin through it’s receptors in Ischemic Brain Injury, using in-vitro/in-vivo mice stroke models
João Carlos Rodrigues Gomes
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-OSD/1012/2014

Protein phosphorylation as a target for Machado-Joseph disease treatment
Tatiana Catarino
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-OSD/1183/2014

CSF and plasma biomarkers in mouse models of dementia – bridging the translational gap
Luis Filipe Oliveira da Maia
Instituto de Biologia Molecular e Celular (IBMC/UP)

PTDC/NEU-OSD/2042/2014

A new mechanism involved in the crosstalk between retinal pigment epithelial and choroidal endothelial cells in age-related macular degeneration
Rosa Cristina S Fernandes
Universidade de Coimbra (UC)

PTDC/NEU-OSD/2087/2014

PGC-1α as a new therapeutic target in the control of brain cholesterol metabolism
Elsa Margarida Teixeira Rodrigues
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/NEU-OSD/2330/2014

Blood-brain barrier dysfunction and cerebral edema triggered by methamphetamine: What is the role of water channel aquaporin-4?
Ana Paula Pereira da Silva Martins
Universidade de Coimbra (UC)

PTDC/NEU-OSD/2758/2014

Critical transitions and nonlinear phenomena in healthy and diseased brain networks
Alexander Goltsev
Universidade de Aveiro (UA)

PTDC/NEU-OSD/3039/2014

Deafblindness: contributing for molecular diagnosis of Usher Syndrome in Portugal
Maria Helena Caria
Fundação da Faculdade de Ciências da Universidade de Lisboa, FP (FFC/FC/ULisboa)

PTDC/NEU-OSD/3114/2014

Treating pain while ameliorating joint pathology in osteoarthritis- the role of RhoA/ROCK signaling pathway
Cecília Juliana Moreira Alves
Instituto Nacional de Engenharia Biomédica - INEB Univ. Porto (INEB Porto)

P2020-PTDC/NEU-OSD/3123/2014

Implantes porosos biodegradáveis para a libertação intravítrea do agonista dos recetores A3 de adenosina para o tratamento do glaucoma
Ana Raquel Sarabando Santiago
Universidade de Coimbra (UC)

PTDC/NEU-OSD/3596/2014

S100B as a new therapeutic target in multiple sclerosis
Adelaide Fernandes
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/NEU-OSD/3654/2014

Osteoarthritic brain: a gender-related evaluation of the time-dependent neurodegenerative events facilitating pain and the development of emotional comorbidities and its pharmacological rescue
Filipa Santos Costa Pinto-Ribeiro
Universidade do Minho (UM)

PTDC/NEU-OSD/3725/2014

Frontotemporal Lobar Degeneration: disclosing early molecular mechanisms of disease
Maria Isabel Jacinto Santana
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-OSD/4528/2014

The changing brain in Alzheimer´s disease: is the retina a mirror of disease onset and progression?
António Francisco Rosa Gomes Ambrósio
Universidade de Coimbra (UC)

PTDC/NEU-OSD/4704/2014

The effect of olfactory deprivation in an animal model of chronic rhinosinusitis with nasal polyps: a morphological, neurochemical and behavioural approach
Kristof Raemdonck
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/NEU-OSD/4797/2014

Non-invasive quantification of the alteration of the Blood-Retinal Barrier in the initial stages of diabetic macular edema using new Optical Coherence methodologies
MARIA DA CONCEIÇÃO LOPES LOBO DA FONSECA
Associação para a Investigação Biomédica e Inovação em Luz e Imagem (AIBILI)

PTDC/NEU-OSD/4987/2014

The microbiota gut-brain axis in Parkinson’s Disease: a novel mechanism underlying neurodegeneration mediated by dietary nitrate
Barbara Rocha
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-OSD/5248/2014

Mechanisms of neuronal cilia maintenance and its functional consequences in the organism
SWADHIN CHANDRA JANA
Fundação Calouste Gulbenkian (FCG)

PTDC/NEU-OSD/5644/2014

Targeting the glycation defenses as a protective strategy for Parkinson’s disease
Hugo Miguel Vicente Miranda
Faculdade de Ciências Médicas (FCM/UNL)

PTDC/NEU-OSD/5852/2014

Validation of SIRT1 as a therapeutic target for preventing lipofuscin accumulation in retinal blood vessels during aging
Jesús Ruberte París
Faculdade de Medicina Veterinária (FMV/ULisboa)

PTDC/NEU-OSD/5969/2014

Turning back the clock on aging with Neuropeptide Y: a potential therapeutic approach to delay skin aging and hair loss
Célia Alexandra Ferreira de Oliveira Aveleira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/NEU-OSD/6001/2014

The eye in Alzheimer´s disease: neurovascular window
João Paulo Pedrosa Branco da Cunha
Unidade Local de Saúde de São José E.P.E. (ULS)

PTDC/NEU-OSD/7115/2014

LONG TERM EFFECTS OF BINGE ALCOHOL CONSUMPTION ON NEUROINFLAMMATION AND NEUROHUMORAL REGULATION
Susana Maria de Sousa da Silva Ferreira
Faculdade de Medicina da Universidade do Porto (FM/UP)