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R&D Projects

Call for SR&TD Project Grants - 2020

Basic Medicine Evaluation Panel – 2020

Coordination

Marcin Majka
Jagiellonian University, Poland

Evaluation

Carsten Ehrhardt
Trinity College Dublin, Ireland
Claudio Mussolino
University of Freiburg, Germany
Cliona O'Farrelly
Trinity College Dublin, Ireland
Frédéric Becq
Hinrich GRONEMEYER
IGBMC, Germany
Ingunn Holen
University of Sheffield, Norway
Jose A.G. Agúndez
Universidad de Extremadura, Spain
José Manuel Afonso Moreira
University of Copenhagen, Denmark
Juan Sastre
University of Valencia, Spain
Karin Dahlman-Wright
Karolinska Institutet, Sweden
Lisardo Bosca
CSIC, Spain
Ludo Van Den Bosch
KU Leuven & VIB, Belgium
Markus Ralser
The Francis Crick Institute, Italy
Massimo Masserini
University Milano Bicocca, Italy
Miroslaw Bik-Multanowski
Jagiellonian University Medical College, Poland
Peter Watt
University of Brighton, United Kingdom
Richard Moriggl
University of Veterinary Medicine, Austria
Shlomo Sasson
The Hebrew University of Jerusalem, Israel
Stephen Hiscox
Cardiff University, United Kingdom
Susanne Brix Pedersen
Technical University of Denmark, Denmark
Tomasz Guzik
University of Glasgow, Poland

Projects assigned

PTDC/MED-ANM/7695/2020

Migration-based mechanisms of arteriogenesis
Claudio Franco
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-GEN/0829/2020

The genetic maze of Familial Amyloid Polyneuropathy ATTRV30M: a genomic approach
Carolina Lemos
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-GEN/1337/2020

The dual role of CPR in cancer development and chemo-therapy: an integrated study.
Francisco Vaz de Carvalho Esteves
Universidade Nova de Lisboa (UNL)

PTDC/MED-GEN/1483/2020

Neurodegenerative Diseases caused by Noncoding Pentanucleotide Repeat Expansions with Insertions: Toxicity and Neuroprotection by RNA-binding Proteins
Isabel Alexandra Azevedo Silveira
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-GEN/1626/2020

Precision genomic medicine empowers deciphering the morbid human genome and its pathomechanisms
Dezso David
Associação para Investigação e Desenvolvimento da Faculdade de Medicina (AIDFM/FM/ULisboa)

PTDC/MED-GEN/1831/2020

Identification of age-at-onset modifiers in Machado-Joseph disease: follow-up of a genome-wide association study
Sandra Martins
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-GEN/1973/2020

HDAC8-spectrum syndrome: a unique human rare disorder as a prototype to dissect new roles of cohesins in intellectual disability and mitotic fidelity
Paula Maria Vieira Jorge
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/MED-GEN/2225/2020

Personalized medicine for nonsense mutations in Cystic Fibrosis
Luka Alexander Clarke
FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências (Fciências.ID)

PTDC/MED-GEN/2328/2020

The quest for male in(fertility) genes through genomics
Alexandra Manuel Ferreira Lopes
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-GEN/3365/2020

Molecular mechanism of cancer susceptibility caused by the Portuguese BRCA2 founder mutation
Maria Carmo-Fonseca
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-GEN/4225/2020

Genetics of obesity: new insights from disease mimicking models
Mónica Sofia Lopes Marques
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-GEN/4542/2020

Genome-wide DNA methylation landscapes in Machado-Joseph disease: identification of modifiers of disease expressivity, CAG repeat instability and transcriptional dysregulation.
Maria Manuela de Medeiros Lima
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-GEN/4639/2020

Solving the unknown genetics of rare diseases
Luís Miguel Ramos Vieira
Instituto Nacional de Saúde Dr. Ricardo Jorge (INSARJ)

PTDC/MED-GEN/5135/2020

Beyond INduced cell moDels -BIND
OLGA ALCINA MARTINS DE OLIVEIRA AMARAL
Instituto Nacional de Saúde Dr. Ricardo Jorge (INSARJ)

PTDC/MED-GEN/5152/2020

Nonsense-mediated mRNA decay: dissecting key players, mechanisms, and their role in tumorigenesis
Luísa Romão
FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências (Fciências.ID)

PTDC/MED-GEN/5170/2020

Development of novel cellular and animal models of NeuroDevelopmental Disorders with motor impairment – platforms for Precision Medicine
Patrícia Espinheira de Sá Maciel
Universidade do Minho (UM)

PTDC/MED-GEN/5273/2020

Evaluating the role of de novo variants in the etiology of neurodevelopmental disorders
Luísa Cristina da Costa Azevedo
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-GEN/5528/2020

Epigenetic specific editing of fetal hemoglobin reactivation for β-hemoglobin disorders treatment through Epigallocatechin-3-gallate and Genistein natural modulators and CRISPR technology.
Edna Soraia Gregório Ribeiro
Instituto Politécnico de Lisboa (IPL)

PTDC/MED-GEN/6178/2020

From molecular diagnosis to personalized treatment - Strategies for the development of a personalized medicine protocol for familial hypercholesterolaemia patients
Mafalda Bourbon
Associação para Investigação e Desenvolvimento da Faculdade de Medicina (AIDFM/FM/ULisboa)

PTDC/MED-GEN/6182/2020

From Symptom Dimensions to Biomarkers: Precision Medicine in Psychiatry -The FSBio Study-
sonija luzi
FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências (Fciências.ID)

PTDC/MED-GEN/6444/2020

RNA mechanisms causing Familial Hypercholesterolaemia
Juliane Menezes
Associação para Investigação e Desenvolvimento da Faculdade de Medicina (AIDFM/FM/ULisboa)

PTDC/MED-GEN/6642/2020

Molecular genetics of growth hormone deficiency
Manuel Lemos
Universidade da Beira Interior (UBI)

PTDC/MED-GEN/6709/2020

(Epi)genetic mechanisms underlying female reproductive failure
Sofia Dória Principe dos Santos Cerveira
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/MED-GEN/6720/2020

RNA como Alvo - Desenvolvimento de abordagens terapêuticas para as Doenças Lisossomais de Sobrecarga através da utilização de oligonucleótidos antisense
Sandra Catarina da Conceição Alves
Instituto Nacional de Saúde Dr. Ricardo Jorge (INSARJ)

PTDC/MED-GEN/6834/2020

Dynamic assessment of miRNAs and proteins as biomarkers of breast cancer drug resistance
António Sebastião Rodrigues
Universidade Nova de Lisboa (UNL)

PTDC/MED-FAR/0201/2020

neonatal Fc receptor-mediated TRAnsport of Functionalized nanoparticles For enhancing Intestinal absorption of anti-diabetiC peptides
Bruno Sarmento
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-FAR/0246/2020

DOPAKYN: Peripheral dopamine-IDO1 dialogue in Parkinson’s Disease
Frederico Guilherme de Sousa da Costa Pereira
Universidade de Coimbra (UC)

PTDC/MED-FAR/0303/2020

Exploring 3D printing technology as a drug delivery platform for individualized therapy of psoriasis: from design to clinical application
Joana Marques Marto
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/MED-FAR/0418/2020

Database on Membrane Association and Permeation by Small molecules
Maria João Pedrosa Ferreira Moreno Silvestre
Universidade de Coimbra (UC)

PTDC/MED-FAR/0529/2020

Potential of Azorean endemic flora as antidepressant agents - efficacy, pharmacokinetics and safety
Olga Maria Duarte Silva
CETNOFARM - Associação para o Desenvolvimento em Etnofarmácia (CETNOFARM)

PTDC/MED-FAR/0601/2020

Preclinical development of the first generation of small-molecule inhibitors of dopamine-induced alpha-synuclein aggregation in Parkinson’s disease
Pedro Miguel Martins
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-FAR/0686/2020

Antimicrobial Peptides Associated to Nanoparticles-in-Vaginal Platforms for the Management of Recurrent Vulvovaginal Candidiasis
José Alberto Gonçalves das Neves
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-FAR/0895/2020

Endoplasmic reticulum-centred therapies for cancer
David Pereira
REQUIMTE - Rede de Química e Tecnologia - Associação (REQUIMTE-P)

PTDC/MED-FAR/1002/2020

Advancing precision therapeutics for implant-associated-bone-infections by 3D-printed multifunctional antibiotic-delivery-devices


Ana Francisca de Campos Simão Bettencourt
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/MED-FAR/1104/2020

Identification and characterization of pharmacological SIRT2 activators for the treatment of cardiometabolic disorders
António Pedro Barros Gomes
Universidade de Coimbra (UC)

PTDC/MED-FAR/1146/2020

Heart talks in cardio-oncology: the role of extracellular vesicles and metabolome changes on the cardiac damage caused by anticancer therapy
Vera Marisa Freitas Costa
REQUIMTE - Rede de Química e Tecnologia - Associação (REQUIMTE-P)

PTDC/MED-FAR/1412/2020

Targeting the brain renin-angiotensin system by nose-to-brain delivery for prevention and treatment of Alzheimer´s disease
Ana Fortuna
Universidade de Coimbra (UC)

PTDC/MED-FAR/1816/2020

Metabolic networks to thrive drug development for orphan diseases and to correct mitochondrial dysfunction in hepatic encephalopathy.
Margarida Maria Fernandes Baptista e Silva
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/MED-FAR/1943/2020

Adverse Drug Reactions: Risk Factors, pharmacogenomics and prevention (ADR_Prevent)
Astrid Vicente
FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências (Fciências.ID)

PTDC/MED-FAR/2094/2020

Preclinical evaluation of minor cannabinoids as anticancer agents: anti-proliferative, anti-inflammatory, and immunomodulatory properties
Bruno Miguel Reis Fonseca
REQUIMTE - Rede de Química e Tecnologia - Associação (REQUIMTE-P)

PTDC/MED-FAR/2180/2020

RIPK3 BIOLOGY AND TARGETING IN METABOLIC LIVER DISEASE
Cecília Maria Pereira Rodrigues
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/MED-FAR/2363/2020

Targeting Parkinson’s Disease Brain affected areas with Multimodal Regenerative Strategies by Blood-Brain Barrier transient openings
Fábio Gabriel Rodrigues Teixeira
Universidade do Minho (UM)

PTDC/MED-FAR/2936/2020

Development of a prophylactic dendritic cell-based vaccine: the only way to halt Alzheimer´s Disease?
Maria Teresa Cruz
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-FAR/3026/2020

Set the clock, repair the block (ChronoBBD): tackling circadian and blood-brain barrier dysfunction in bipolar disorder
Joana Bicker de Melo Alves Aparício
Universidade de Coimbra (UC)

PTDC/MED-FAR/3231/2020

Nanomedicine in the next era of stroke management: a neuron fond carrier for therapeutic nucleic acids towards the brain.
Sofia Santos
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-FAR/3249/2020

Role of obesity in multiple sclerosis: targeting oligodendrocyte-related miRNAs to induce remyelination
Andreia Pereira Barateiro Macedo
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/MED-FAR/3493/2020

Unravelling the pharmacological mechanisms of novel chromene-based compounds for triple negative breast cancer therapy
Marta Sílvia Freitas da Costa
Universidade do Minho (UM)

PTDC/MED-FAR/4029/2020

Destabilization of synaptic glutamate receptors containing GluN2B subunits: a novel strategy for prevention of epilepsy
Filipe Valente Duarte
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-FAR/4306/2020

Microbubble-assisted delivery of modulated extracellular vesicles into the heart

Arnab Banerjee
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-FAR/4328/2020

Identifying drug repurposing opportunities in pancreatic and lung cancers
Cristina Pinto Ribeiro Xavier
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-FAR/4368/2020

Pharmacological regulation of BRCA1/2-mediated DNA repair for personalized cancer prevention and therapy
Lucília Helena Ataíde Saraiva
REQUIMTE - Rede de Química e Tecnologia - Associação (REQUIMTE-P)

PTDC/MED-FAR/4420/2020

Boosting protein quality control mechanisms as a neuroprotective strategy for treating Brain Ischemia - the singular case of the Ubiquitin Pathway
Ivan Salazar
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-FAR/4443/2020

PURINE(OAB)TARGETS - Pivotal role of purinergic signalling in ischemia/reperfusion in patients with bladder outflow obstruction and hyperactivity: looking for novel therapeutic targets
Paulo Correia de Sá
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/MED-FAR/4525/2020

Effect of newly synthesized chrysin-loaded silica mesoporous nanoparticles on metabolic syndrome
Fátima Martel
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/MED-FAR/4634/2020

PKBar - Physiological and pharmacokinetic changes in the bariatric patient
Paulo Jorge Pereira Alves Paixão
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/MED-FAR/4680/2020

Drug discovery pipeline for breast cancer brain metastasis treatment
Maria Alexandra de Oliveira Silva Braga Pedreira de Brito
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/MED-FAR/4692/2020

Therapeutic targeting of splicing in myelodysplastic syndromes
Maria Joana Pinto Desterro
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-FAR/4712/2020

Exploring the old and novel anti-cancer agents – targeting melanoma bioenergetics, TRIB2 and other effectors to tackle therapy resistance and improve pharmacological success.
Ana Luísa De Sousa Coelho
Universidade do Algarve (UAlg)

PTDC/MED-FAR/4722/2020

Near infrared-responsive gold nanorods for improving ocular drug delivery efficacy
Elisa Regina Figueiras Julião Inácio de Campos
Universidade de Coimbra (UC)

PTDC/MED-FAR/4779/2020

Three-dimensional printing for on-demand pediatric pharmaceutical formulations in hospital
MARLENE SUSANA DIONISIO LÚCIO
Universidade do Minho (UM)

PTDC/MED-FAR/4945/2020

Preventing epileptogenesis with vasoactive intestinal peptide (VIP) recptor ligands: a role for VPAC1 receptors
Diana Lina Jerónimo da Cunha Reis
FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências (Fciências.ID)

PTDC/MED-FAR/5218/2020

Antiepileptic Activity of Cannabidiol at the Adenosine A2A-Cannabinoid CB1 Receptor Heterotetramer
Attila Köfalvi
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-FAR/5371/2020

Crosstalk between astrocytic adenosine A2A receptors and connexins 43 in Alzheimer´s disease
PAULA MARIA GARCIA AGOSTINHO
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-FAR/5412/2020

Novel drugs to restore endogenous BDNF-mediated neuroprotection in Alzheimer’s disease
Maria José de Oliveira Diógenes Nogueira
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-FAR/5500/2020

Antiviral activity of cyclodextrins and cyclodextrin drug conjugates
Helena Maria Cabral Marques
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/MED-FAR/5517/2020

I got you in my skin: Noninvasive TARGET THERAPY to Skin Fibroblasts in Scleroderma
Sandra Simões
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/MED-FAR/5520/2020

Relaxin-2 and pulmonary arterial hypertension: pathophysiological role and therapeutic potential
Rui Adão
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/MED-FAR/5550/2020

Targeting adenosine signaling to induce adipose tissue browning: from animal to Human studies
Joana Filipa Canais da Costa Sacramento
Universidade Nova de Lisboa (UNL)

PTDC/MED-FAR/5576/2020

Biomarcadores do purinoma na osteoporose: bases para a regeneração do osso humano envelhecido
José Bernardo Almeida Garrett de Noronha Matos
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/MED-FAR/5798/2020

MitoEdaravone a novel therapeutic approach for ALS: Increasing mitochondria health by tackling oxidative stress and modulating NF-kB and HIF transcriptional activity.
Pedro Henrique Gomes Soares
Faculdade de Ciências da Universidade do Porto (FCUP/UP)

PTDC/MED-FAR/6142/2020

Identification of Novel CFTR Potentiators Among FDA-approved Drugs
Miquéias Lopes-Pacheco
FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências (Fciências.ID)

PTDC/MED-FAR/6201/2020

Targeting adenosine A2A receptors in post-traumatic stress disorder
Ana Patrícia Figueiredo Rocha Simões
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-FAR/6256/2020

ROS-Cleavable PEGylated mucus-penetrating Nanoparticles for drug delivery into inflamed intestine
Rute Sofia Gonçalves Nunes
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-FAR/6359/2020

Identification of novel therapeutic approaches to rescue CFTR mutations
Iris Silva
Centro de Ciências do Mar (CCMar)

PTDC/MED-FAR/6477/2020

BraveHEART: Targeting Mitochondria with Dietary Polyphenols to Decrease Cardiac Complications in Non-Alcoholic Fatty Liver Disease
José Carlos Santos Teixeira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-FAR/6639/2020

Cannabinoids as a potential adjuvant therapy for the treatment of hormone-dependent breast cancer: unveiling its anti-tumor efficacy and clinical application
Cristina Isabel Borges Dias Amaral
REQUIMTE - Rede de Química e Tecnologia - Associação (REQUIMTE-P)

PTDC/MED-FAR/6736/2020

Exploring the therapeutic action of Levetiracetam after a Spinal Cord Injury: The Path for Clinical Translation
Nuno André Martins Silva
Universidade do Minho (UM)

PTDC/MED-FAR/6760/2020

New Repurposed Drugs for SARS-CoV-2 using an alternative target
Nuno Vale
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-FAR/6928/2020

New drugs for Neisseria gonorrhoeae – an innovative approach for drug discovery in the era of antimicrobial resistance
Liliana Rodrigues
Universidade Nova de Lisboa (UNL)

PTDC/MED-FAR/6962/2020

Flavonoids to modulate adipocytes phenotype and the inter-tissue signaling networks: a therapeutic approach for Type 2 diabetes
Paula Cristina Branquinho de Andrade
REQUIMTE - Rede de Química e Tecnologia - Associação (REQUIMTE-P)

PTDC/MED-FAR/6968/2020

Neuropeptide kyotorphin impact on the microvascular lesions in diabetes and its application on diabetic retinopathy.
Ana Rosa Miranda dos Santos Silva Herdade
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-FAR/7381/2020

A Senescência na pele como alvo para prevenir o envelhecimento do organismo
CLÁUDIA MARGARIDA GONÇALVES CAVADAS
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-FAR/7605/2020

Antibody encapsulation into polymer nanoparticles as a new approach for lung cancer treatment
Pedro Fonte
Centro de Ciências do Mar (CCMar)

PTDC/MED-FAR/7616/2020

Modulating the endocannabinoid system in ALS: development of novel multi-targeted treatment approach
Joaquim Alexandre Ribeiro
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-FAR/7768/2020

Activation of the sirtuin-1/NAD+ pathway: a gene therapy approach to Machado-Joseph disease
LUÍS FERNANDO MORGADO PEREIRA DE ALMEIDA
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-TOX/0017/2020

Protecting the brain with Semaglutide under middle-aged high cardiovascular risk: from the bench to bedside
Ana Isabel Marques Duarte
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-TOX/0295/2020

Insulin Resistance: developing a human in vitro hepatic disease model for tailored MSC-based therapies
Joana Paiva Gomes Miranda
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/MED-TOX/1120/2020

Role of HDAC inhibitors in chronic stress mouse model
Ildete Luísa de Araújo Ferreira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-TOX/2251/2020

SCREENTOX: SCREENing the TOXicity of excipients for pulmonary delivery applications
Ana Margarida Moutinho Grenha
Centro de Ciências do Mar (CCMar)

PTDC/MED-TOX/2398/2020

Opening the therapeutic window: Precision chemotherapy based on redox-active drugs in non-small cell lung cancer
Nuno Filipe da Rocha Guerreiro de Oliveira
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/MED-TOX/3863/2020

Papel da Dehidroorotate Desidrogenase na Cardiotoxicidade Tardia Resultante da Quimioterapia com Antraciclinas
Paulo Jorge Gouveia Simoes Da Silva Oliveira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-TOX/4265/2020

Colours of arterial hypertension
Sofia Azeredo Gaspar Pereira
Universidade Nova de Lisboa (UNL)

PTDC/MED-TOX/5044/2020

ApoE4: A mitochondrial shaping factor in early stages of Alzheimer’s disease
Ana Cristina Carvalho Rego
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-TOX/6361/2020

New Psychoactive Substances - Maternal Drug Use and its Effect on Neonatal Brain Function
Cristina Sampayo
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/MED-TOX/7200/2020

The role of Lead EXposure in the nervous system and in the onset and progression of ParkinsOn’s diseaSE
Vera Lúcia Poço Geraldes
Associação para Investigação e Desenvolvimento da Faculdade de Medicina (AIDFM/FM/ULisboa)

PTDC/MED-FSL/1460/2020

FIBROBLAST GROWTH FACTOR-21, A KEY PLAYER IN PREGNANCY CARDIAC REMODELLING AND A PROMISING TARGET FOR HEART FAILURE.
Inês Falcão Pires
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/MED-FSL/1937/2020

Desvendando o papel do transporte de insulina pelas vesículas extracelulares na saúde e no dismetabolismo
Maria Paula Borges de Lemos Macedo
Universidade Nova de Lisboa (UNL)

PTDC/MED-FSL/2221/2020

Untangling the involvement of WWOX in skeletal muscle insulin resistance: a potential therapeutic target
Cristina Carvalho
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-FSL/2578/2020

Synaptic regulation by chronic stress-induced microRNA-186-5p in the prefrontal cortex
Paulo César Silva Pinheiro
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-FSL/2802/2020

Epidermal Growth Factor Receptor 4 signaling in pulmonary arterial hypertension
Pedro Mendes Ferreira
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/MED-FSL/2898/2020

Novel therapeutic strategies for vascular dysfunction in metabolic disorders
Cristina Maria Tristão Sena
Universidade de Coimbra (UC)

PTDC/MED-FSL/4681/2020

Metabolic reprogramming as a defence strategy to infection
Miguel Amado Franco Parreira Soares
Fundação Calouste Gulbenkian (FCG)

PTDC/MED-FSL/5098/2020

Diabesity: Tackling vascular complications by Xanthohumol
Raquel Soares
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/MED-FSL/5700/2020

Cerebellar dysfunction in neuropsychiatric disorders
Ângela Rosalina Sanches Inácio
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-FSL/6186/2020

O papel da Sirtuina 2 no desenvolvimento do cérebro, envelhecimento e neurodegeneração
Maria Teresa Albuquerque Santos Faria Pais
Fundação Calouste Gulbenkian (FCG)

PTDC/MED-FSL/6304/2020

UnDerstanding the role of epigenetic Reprogramming In liVer rEgeneratioN
Carlos Palmeira
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-FSL/6451/2020

iRHom2 in the crosstalk of cardiovascular and mEtabolic Related cOnditions
Daniela Maria Miranda da Silva
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/MED-FSL/6786/2020

From core to shell: intracellular orchestration of local events during plasma membrane repair

Sandra Sousa
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-FSL/6848/2020

Urocortin-2 in heart failure with Preserved Ejection fraction - pathophysiological and therapeutic effects
Carmen Dulce da Silveira Brás Silva
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/MED-FSL/7280/2020

Therapeutic strategies to influence reconsolidation of traumatic memories in post-traumatic stress disorder.
Mónica Isa Moreira Rodrigues
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/MED-FSL/7625/2020

About the Gut-Brain-Skin connections


Sergio Faloni de Andrade
COFAC, Cooperativa de Formação e Animação Cultural, CRL (COFAC)

PTDC/MED-FSL/7658/2020

Integrating Ciculatory Function: Coupling the Heart and Arteries
Luis Afonso Bras Simoes Rosario
Associação para Investigação e Desenvolvimento da Faculdade de Medicina (AIDFM/FM/ULisboa)

PTDC/MED-PAT/0078/2020

Tackling the metabolism of plasmacytoid Dendritic Cells as a means to fight lung fibrosis
Catarina R Almeida
Universidade de Aveiro (UA)

PTDC/MED-PAT/0127/2020

Nuclear Invasive Hallmarks: a novel readout of cell-cell and cell-ECM mechanical imbalance
Raquel Seruca
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-PAT/0160/2020

Discovery and development of a disease-modifying drug for Alzheimer´s Disease: small-molecule chaperones (SMCs) of the transthyretin/Aβ interaction
Isabel dos Santos Cardoso
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-PAT/2395/2020

The dark side of transthyretin when breaks the heart
Maria João Gameiro de Mascarenhas Saraiva
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-PAT/2676/2020

Leuko-axonopathy caused by dysregulated fatty acid metabolism: Unravelling determinants, mechanisms and pre-clinical therapies.
Pedro Miguel Teixeira Brites
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-PAT/2753/2020

Unravelling the mechanism of onset of LAMA2-congenital muscular dystrophy.
Solveig Thorsteinsdottir
FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências (Fciências.ID)

PTDC/MED-PAT/4416/2020

Targeting Renal Ferroptosis in Disease Tolerance Establishment to Malaria
Qian Wu
Fundação Calouste Gulbenkian (FCG)

PTDC/MED-PAT/4640/2020

Exploring mitochondria as a mechanistic link between diabetes and depression: is a mitochondrial-directed therapy a solution?
Susana Cardoso
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-PAT/5039/2020

Glycosylation patterns in HER2 positive breast cancer
António Polónia
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-PAT/5304/2020

Purinergic metabolism and adenosine A2A receptors in the aging gut microbiota phenotype
Lisa Catarina Oliveira Rodrigues
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-PAT/5364/2020

Dissecting the role of NRF2 and its therapeutic targeting in preclinical models of iron overload disorders
Tiago Pereira de Lacerda Costa Duarte
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-PAT/5591/2020

Harnessing spinal cord injury Inflammation through Peripheral Sympathetic signaling
Susana Isabel Gonçalves Monteiro
Universidade do Minho (UM)

PTDC/MED-PAT/6461/2020

The role of phospholipase D2 in Alzheimer’s disease
Tiago Gil Oliveira
Universidade do Minho (UM)

PTDC/MED-PAT/7564/2020

Novel anti-angiogenic therapeutics for cancer and retinopathies
Francisca Ferreira de Vasconcelos
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-PAT/7576/2020

Glycosylation and cancer: treatment sweet spot
Carlos Resende
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/0048/2020

EVglycanID - Decoding Extracellular Vesicles glycan signatures to decipher their message in cancer cell communication
Ana Maria Rodrigues Leite de Magalhães
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/0052/2020

Deciphering the hidden message in m6A RNA methylation in gastric cancer
Raquel Maria da Silva Graça Almeida
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/0114/2020

Cell-Cell ADHESION: The Achilles’s heel of circulating inflammatory breast cancer cells
Joana Cancela de Amorim Falcão Paredes
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/0177/2020

Early biomarkers of cancer progression from pre-malignant conditions: defining the roles of NAMPT and NAPRT.
Raquel M Silva
Universidade Católica Portuguesa (UCP)

PTDC/MED-ONC/0179/2020

Microenvironment, the shelter of brain malignancies: bidirectional communication between glia and brain tumors
Catarina C F Homem
Universidade Nova de Lisboa (UNL)

PTDC/MED-ONC/0286/2020

Multiple Biomarker strategy to improve early risk stratification for melanoma metastases
Marta Pojo
Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE (IPO Lisboa)

PTDC/MED-ONC/0317/2020

RANKL/RANK pathway blockade: an opportunity for drug repurposing in metastatic triple-negative breast cancer
Sandra Cristina Cara de Anjo Casimiro
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-ONC/0402/2020

IMmunoModulation in PAncreatic Cancer: Exosomes Take Center Stage
Sonia Melo
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/0711/2020

Cancer adaptation to proteotoxic stress: a new opportunity to identify and revert resistance to anti-cancer therapy
Luisa Alejandra Helguero
Universidade de Aveiro (UA)

PTDC/MED-ONC/1216/2020

New Theranostic Pharmaceuticals for Oncologic PET-Guided-Boron Neutron Capture Therapy.
Abilio Jose Fraga do Nascimento Sobral
Universidade de Coimbra (UC)

PTDC/MED-ONC/1360/2020

Three-Dimensional Models of Cancer to Increase the Predictive Value of Preclinical Evaluation of Antimitotic Agents
Hassan Bousbaa
Cooperativa de Ensino Superior Politécnico e Universitário, CRL (CESPU)

PTDC/MED-ONC/1532/2020

Development of an animal-free pre-clinical model to assess response to immunotherapies and new combined targeted therapies for personalized melanoma patient’s treatment
Helena Isabel Martins Pópulo
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/2195/2020

Unravelling cell-cell interactions in the breast tumour microenvironment by integrating single- and paired-cell transcriptomics
NUNO LUÍS BARBOSA MORAIS
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-ONC/2266/2020

PPARg targeting: A metabolic challenge to boost bladder cancer immunotherapy
Julieta Alexandra Pereira Afonso
Universidade do Minho (UM)

PTDC/MED-ONC/2390/2020

Investigation on the role of glucosensing receptors in glioblastoma metabolism
Cecília Reis Alves SANTOS
Universidade da Beira Interior (UBI)

PTDC/MED-ONC/2470/2020

Functional characterization of Xeroderma Pigmentosum D mutations in Drosophila
Pedro Manuel Dias Neto Domingos
Universidade Nova de Lisboa (UNL)

PTDC/MED-ONC/2474/2020

the impact of hyPoxia on anti-coLon cAnCEr iMmune rEsponse: implications to immuNoTherapy
Ângela Margarida Amorim Costa
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/2553/2020

Regulation of cellular glucose uptake through protein kinase WNK1
Peter Jordan
FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências (Fciências.ID)

PTDC/MED-ONC/2622/2020

Targeting resistance in renal cell cancer: exploitation of novel targeted inhibitors
Maria de Fátima Monginho Baltazar
Universidade do Minho (UM)

PTDC/MED-ONC/2669/2020

Novel synthetic lethal approaches that drive catastrophic genomic instability and cancer cell death
Maria João Rodrigues da Silva
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-ONC/2826/2020

Unraveling the connection between cell death and immunity following 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins based photodynamic therapy
Mafalda Sofia Laranjo Cândido
Universidade de Coimbra (UC)

PTDC/MED-ONC/2832/2020

Landscape of somatic and germline genetic alterations in ampullary carcinomas
Pedro Miguel Teixeira Pinto
Instituto Português de Oncologia do Porto Francisco Gentil, EPE (IPO Porto)

PTDC/MED-ONC/2841/2020

HOXB7 function in Breast Cancer and its potential as therapeutic target.
Carla Renata Gonçalves de Freitas
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/3084/2020

Decode the Link between Histone Overexpression and Gastric Cancer.
Carla Marina Gonçalves Leite
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/3192/2020

CCL18 in colon cancer progression: new opportunities for therapeutic intervention
Ana Patrícia Pereira Cardoso
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/3479/2020

Cracking the (tubulin) code of mitosis and respective implications for human cancers
Helder Jose Martins Maiato
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/3534/2020

Investigating the essential roles of tumor glycosylation in fat remodeling during cancer progression
Daniela Sofia Pereira Freitas
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/3915/2020

Preclinical Exploitation of a Combined Targeted Therapy for ETV1-overexpressed Prostate Carcinomas
Paula Cristina Martins Santos Paulo
Instituto Português de Oncologia do Porto Francisco Gentil, EPE (IPO Porto)

PTDC/MED-ONC/3936/2020

The Human MicroBiome in Renal Cell Carcinoma: Stepping Forward in Cancer Understanding and Management.
Inês Soares Alencastre
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/3941/2020

PLCγ1-mediated Glycolytic Regulation in Colorectal Cancer
Marta Sofia Alves Martins
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-ONC/3988/2020

Tapping the potential of aberrant glycosylation for improved cancer immunotherapies
Daniel Vieira Noro e Silva Sobral
NOVA.ID.FCT - Associação para a Inovação e Desenvolvimento da FCT (NOVA.ID.FCT)

PTDC/MED-ONC/4092/2020

SPOTON - Anti-diabetic drugs and breast cancer therapy: an in vitro comprehensive proteomic profiling and the search of the precise therapeutic approach
Francisco Amado
Universidade de Aveiro (UA)

PTDC/MED-ONC/4167/2020

ovErcomiNg DrUg Resistance IN Glioblastoma
Bibiana Ferreira
Universidade do Algarve (UAlg)

PTDC/MED-ONC/4190/2020

Biological effect of Clinically Relevant Collagen type I Fragments in the Tumour Microenvironment
Ana Cláudia Martins Cavaco
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-ONC/4339/2020

Deciphering the therapeutic relevance of the tumour suppressor gene SPINT2 silencing in melanoma
MARTA SOFIA DE CARVALHO RIBEIRO VIANA PEREIRA
Universidade do Minho (UM)

PTDC/MED-ONC/4455/2020

Combined immUNotherapeutIC approach for targeting bone marrow microenvironment in Multiple Myeloma
Cristina Maria Godinho Pires João
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/MED-ONC/4548/2020

Function of ZEB transcription factors as signaling integrators in tumor niches of glioblastoma
Diogo Pinto da Cruz Sampaio e Castro
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/4759/2020

Characterization of the molecular mechanisms leading to CFTR deficiency in sporadic colorectal cancer
Paulo Henrique Carrasquinho de Matos
FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências (Fciências.ID)

PTDC/MED-ONC/4810/2020

ELECTRA: EndosomaL rEcycling ConTRols invasion of highly aggressive cAncer
Sandra Tavares
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/4816/2020

Towards new strategies for brain tumors theranostics: a holistic view around WNT6 oncogene
Céline Saraiva Gonçalves
Universidade do Minho (UM)

PTDC/MED-ONC/5089/2020

Twist & and Shut: Disturbing telomerase in cancer through nucleic acid therapeutic approach
Ana Paula Soares Dias Ferreira
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/5310/2020

Nonalcoholic steatohepatitis (NASH): comprehensive analysis of molecular and morphological alterations occurring in cirrhosis development and malignancy transformation.
Adhemar Longatto
Universidade do Minho (UM)

PTDC/MED-ONC/5344/2020

Clinical and therapeutic validation of CCL2/CCR2 signaling pathway in metastatic medulloblastoma
Cláudia Maria Coelho de Faria
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-ONC/5415/2020

Systemic cholesterol and its receptors in brain metastasis
Ana Luísa Ferro Espadanal Torres de Magalhães Canha
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-ONC/5457/2020

Is CDK12 a potential drug target in pancreatic cancer?
Marilia Cravo
Associação para Investigação e Desenvolvimento da Faculdade de Medicina (AIDFM/FM/ULisboa)

PTDC/MED-ONC/5553/2020

Comparing pediatric and adult cancer progression and therapy response
Adriana Sánchez-Danés
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/MED-ONC/5563/2020

Ctrl+ALT+Cel: ATRX control in ALT and in the pancreas beta cell.
JOÃO PEDRO RICO DE OLIVEIRA VINAGRE
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/5759/2020

Castration Resistant Prostate Cancer: Decoding the clinical relevance of Non-coding RNAs m6A modifications
Carmen Jerónimo
Instituto Português de Oncologia do Porto Francisco Gentil, EPE (IPO Porto)

PTDC/MED-ONC/5765/2020

MITOTERT - Targeting the mitochondrial role of TERT to open new therapeutic windows
Marcelo José Marques Correia
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/5769/2020

Metabolic-Epigenetic crosstalk in tumour microenvironment: towards a new therapeutic strategy for renal cell carcinoma
Rui Manuel Ferreira Henrique
Instituto Português de Oncologia do Porto Francisco Gentil, EPE (IPO Porto)

PTDC/MED-ONC/5795/2020

Micropeptides of nuclear and mitochondrial origin: A promising novel strategy to overcome chemotherapy resistance and increase safety and efficacy
Ricardo Marques
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-ONC/5965/2020

Fishing for molecular mechanisms of innate immune evasion and rejection
Rita Leonor Alvares Cabral de Figueiredo FIOR Sousa Soares
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/MED-ONC/6048/2020

Exploiting the immune landscape of HOXA9/WNT6-driven glioblastoma: opportunities for novel precision therapies
Bruno Costa
Universidade do Minho (UM)

PTDC/MED-ONC/6188/2020

RalGPS2 and YAP/TAZ in Human Malignancies: from regulatory mechanisms to the development of innovative therapies
ADRIANA OLIVEIRA DOS SANTOS
Universidade da Beira Interior (UBI)

PTDC/MED-ONC/6420/2020

Thyroid cancer: DNA repair profile as a key element on the outcome of iodine-131 treatment
Octávia Gabriela da Silva Viegas Nené Monteiro Gil
Associação do Instituto Superior Técnico para a Investigação e o Desenvolvimento (IST-ID)

PTDC/MED-ONC/6469/2020

Exploration and discover of metabolic traits of Breast Cancer in Lung Metastasis and therapy
Teresa Laura Mendes Serafim
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-ONC/6561/2020

Microenvironmental cues controlling leukemic cell trafficking from primary to distant organs
Ivette Pacheco Leyva
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/6656/2020

Targeting immunogenic cell death to treat liver cancer
Marta Bento Afonso
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/MED-ONC/6829/2020

Regulation of gamma-delta T cells in the tumor microenvironment and their manipulation towards immunotherapy of solid cancers
Bruno Miguel de Carvalho Silva Santos
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-ONC/7055/2020

MitochOndrial Dysfunction: impact of metabolism in Epigenetic RemodeliNg – MODERN
Valdemar de Jesus Conde Máximo
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/7216/2020

Decoding cytoskeletal dynamics-mediated activation of Serum Response Factor Signaling to TARget cancer Stem-like cells in triple negative breast cancer
PATRÍCIA ISABEL DA SILVA GUERREIRO
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/7325/2020

3D prostate cancer spheroids models as mimics of in vivo conditions: a personalized approach to define new hormone treatment resistance biomarkers
RUI Manuel de MEDEIROS Melo Silva MEDEIROS
Instituto Português de Oncologia do Porto Francisco Gentil, EPE (IPO Porto)

PTDC/MED-ONC/7328/2020

The impact of IL-7R, MYH10 and sphingosine kinases on leukemia development, CNS involvement and resistance to therapy
João Pedro Taborda Barata
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-ONC/7418/2020

Cell proliferation control
ÁLVARO AUGUSTO MARQUES TAVARES
Universidade do Algarve (UAlg)

PTDC/MED-ONC/7434/2020

The first functional, phenotypic and clinical study of the most frequently mutated proto-oncogene in cancer: Delta160p53 – in search of a target for “universal” cancer therapy 
Marco Candeias
FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências (Fciências.ID)

PTDC/MED-ONC/7470/2020

Colon cancer & natural compounds - a theranostic approach
Ana Cristina Aguiar dos Santos
Universidade de Coimbra (UC)

PTDC/MED-ONC/7527/2020

Do Major Histocompatibility Complex class I (MHC-I)-negative tumor cells display cancer stem cell properties? Clinical implications in response to therapy and tumor recurrence
Mireia Castillo-Martin
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/MED-ONC/7583/2020

The crosstalk between acute myeloid leukemia cells and monocytes in the remodeling of the vascular niche
Delfim Duarte
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/7585/2020

Unveiling the role of DNA damage as a driver of breast cancer metastasis
Naike Salvador Moreno
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-ONC/7666/2020

Dissect the tumor microenvironment to battle cancer radioresistance and immune escape
Maria José Cardoso Oliveira
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-ONC/7681/2020

Tracking the mechanisms of breast cancer cell invasion: Arl13b crosstalk with Hedgehog signaling
CRISTINA MARIA TAVARES LINO CASALOU
Universidade Nova de Lisboa (UNL)

PTDC/MED-ONC/7864/2020

Study of Alternative Lengthening of Telomeres-associated telomeric replicative stress alleviators - paving avenues towards innovative anti-cancer therapies
Patrícia Alexandra Lona Abreu
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-ONC/7898/2020

Mutational analysis of gastric lavage and circulating tumor DNA as a tool for cancer screening and early detection in carriers of gastric cancer predisposition variants
Manuela Cristina Dias Pinheiro
Instituto Português de Oncologia do Porto Francisco Gentil, EPE (IPO Porto)

PTDC/MED-ONC/7986/2020

Unravelling crucial steps towards metastatic competence
Sérgio Dias
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-OUT/0030/2020

Osteopenia and Mycobacterial Infection: understanding of the role of infection in bone loss
Ana Cordeiro Gomes
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-OUT/0439/2020

FUNCTIONAL ANALYSIS OF TAUOPATHY SUPPRESSION BY CDC25 PHOSPHATASES
Carla Sofia Silva Lopes
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-OUT/0751/2020

MITOCROSS: disclosing epidemiology and mitochondria-intracellular organelle crosstalk in LHON
Manuela Grazina
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-OUT/0761/2020

Gastric cancer: Outer membrane vesicles as Trojan horses for Helicobacter pylori
Ceu Figueiredo
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-OUT/2172/2020

Risk stratification in response to ionizing radiation in Hereditary Breast and Ovarian Cancer Syndrome associated with BRCA1 / 2 genes
Maria Filomena Rabaça Roque Botelho
Universidade de Coimbra (UC)

PTDC/MED-OUT/2249/2020

An Eye into ADHD: Can the retina be used as a diagnostic support tool for Attention-Deficit/Hyperactivity Disorder?
Ana Paula Pereira da Silva Martins
Universidade de Coimbra (UC)

PTDC/MED-OUT/2307/2020

Tackling heterogeneous Treg cell subpopulations in cancer
Carla Marina Pereira Gomes
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-OUT/2318/2020

CONCOEUR: Unveiling a new role for Cx43 in the nucleus and its implication in heart failure
Henrique Girao
Universidade de Coimbra (UC)

PTDC/MED-OUT/2498/2020

Embryonic reprogramming underlying Diabetes in Pregnancy: relevance for pulmonary growth, development and disease
Rute S Moura
Universidade do Minho (UM)

PTDC/MED-OUT/2747/2020

Rejuvenescimento farmacológico através da reparação de DNA e remodelação epigenética
Elsa Logarinho
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-OUT/3025/2020

Female-biased autoimmunity: the contribution of the X chromosome to Systemic Lupus Erythematosis
Simão José Teixeira da Rocha
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-OUT/3179/2020

MiNDna - Modeling Neurodevelopmental Disorders using Dental Stem Cell-Derived Brain Organoids
Catarina Morais Seabra
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-OUT/3643/2020

Multimodal imaging approach in Alzheimer disease. Is it cardio-renal axis a window to neurovascular perfusion changes?
José Vitor Oliveira Sereno
Universidade de Coimbra (UC)

PTDC/MED-OUT/3728/2020

Dementia associated with HIV infection - study of infectious and inflammatory mechanisms mediated by extracellular vesicles
José Miguel Azevedo Pereira
FARM-ID, Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento (FARM-ID)

PTDC/MED-OUT/3759/2020

Endometriosis – unravelling the intricate crosstalk among endometrium, adipose tissue and neurons in the search of novel therapeutic targets.
Delminda Gamelas Neves Lopes de Magalhaes
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/MED-OUT/3848/2020

Role of androgens disruptors in hypertensive disorders of pregnancy
Maria Elisa Cairrao Rodrigues Oliveira
Universidade da Beira Interior (UBI)

PTDC/MED-OUT/4114/2020

Innovative proteomic-metabolomic analysis in ageing looking for markers of cardiovascular diseases
Ignacio Verde
Universidade da Beira Interior (UBI)

PTDC/MED-OUT/4229/2020

Impact of a novel vaccine against Group B Streptococcus on host metabolism
Paula Ferreira
Instituto de Ciências Biomédicas Abel Salazar da universidade do Porto (ICBAS/UP)

PTDC/MED-OUT/4245/2020

Understanding the cross-talk between lysosome dysfunction and cell senescence in atherosclerosis
Otília Vieira
Universidade Nova de Lisboa (UNL)

PTDC/MED-OUT/4296/2020

FATE: Impacto do FLT3 na função das célulAs esTaminais hEmatopoiéticas humanas
Perpetua Pinto do Ó
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-OUT/4301/2020

Decoding the Role of DNA Break-Induced Transcription in Ageing
SÉRGIO ALEXANDRE FERNANDES DE ALMEIDA
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)

PTDC/MED-OUT/4406/2020

Sympathetic Nervous System and Macrophages: joint forces to fight periprosthetic inflammation
Cecília Juliana Moreira Alves
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-OUT/5000/2020

Epicardial adipose tissue-derived exosomal miRNAs as therapy for heart failure
Ana Burgeiro
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-OUT/5314/2020

Therapeutical potential of targeting adenosine A2A receptors in a mouse model of Angelman Syndrome
Paula Margarida Gomes Canas
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-OUT/5441/2020

Modulation of cholesterol levels in the hypothalamus: a new player in whole-body metabolism?
David dos Santos Albuquerque
Universidade do Algarve (UAlg)

PTDC/MED-OUT/5627/2020

Deironing: Preclinical development of innovative mitochondrial-directed iron chelators
Ester Sofia Teixeira Benfeito
Faculdade de Ciências da Universidade do Porto (FCUP/UP)

PTDC/MED-OUT/5637/2020

Fixing the clock on obesity, ataxin-2 as a new timekeeper
Sara Matias Carmo Silva
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-OUT/6110/2020

Deciphering the genome-wide mechanisms of evolution towards echinocandin resistance in Candida glabrata and Candida auris, aiming a targeted, personalized therapy
Cidalia Pina Vaz
Faculdade de Medicina da Universidade do Porto (FM/UP)

PTDC/MED-OUT/6426/2020

Protein Tyrosine Phosphatase 1B inhibition as a novel therapy for diabetic foot ulcers
Ermelindo Carreira Leal
Centro de Neurociências e Biologia Celular (CNBC/UC)

PTDC/MED-OUT/6524/2020

Clear out Senescence to slow in aging: tackling adipose tissue dysfunction
Adriana Raquel Rodrigues
Instituto de Investigação e Inovação em Saúde da Universidade do Porto - Associação (i3S)

PTDC/MED-OUT/6859/2020

Unraveling the mechanisms of resistance to vascular dysfunction and atherogenesis: the role of Testin
Diogo André Afonso da Fonseca
Universidade de Coimbra (UC)

PTDC/MED-OUT/7348/2020

Metabolic reprogramming and cell fate during regeneration
António Alfredo Coelho Jacinto
Universidade Nova de Lisboa (UNL)

PTDC/MED-OUT/7699/2020

Early lung cancer diagnosis (ELCD) - integrated approach using volatile organic compounds, anatomical pathology, low-dose CT scan and stratification of exhaled breath profiles by Artificial Intelligence (AI-based) tools
Jorge Manuel Costa da Cruz
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud (FC Champalimaud)

PTDC/MED-OUT/8010/2020

Rejuvenating Strategies for Stem Cell-Based Therapies in the Aged Skeletal Muscle
Pedro Miguel Sousa Corado Victor
Instituto de Medicina Molecular João lobo Antunes (IMM/FM/ULisboa)